ANALYSIS OF THE RELATIONSHIP BETWEEN CHROMOSOME POLYMOPHISMS AND INFERTILITY
Journal Title: Kocatepe Medical Journal - Year 2023, Vol 24, Issue 2
Abstract
OBJECTIVE: It was aimed to compare the group consisting 391 cases (178 females, 213 males) diagnosed with infertility and performed karyotype analysis, and a control group consisting of 40 couples in terms of the chromosomal polymorphisms. MATERIAL AND METHODS: Chromosomal polymorphisms of the case group were evaluated retrospectively using archive files and preparations. Closed lymphocyte culture was performed from the blood samples of the control group and karyotype analysis was performed. RESULTS: Total satellite polymorphisms (13 ps+, 14 ps+, 15 ps+, 21 ps+ and 22 ps+) were found to be significantly higher in the female case group than in the control. No gender-related difference was detected in the distribution of 1qh+, 9qh-, inv(9), 13ps+, 14ps+, 15ps+, 16qh+, 21ps+ and 22ps+ polymorphisms in the case group. The most common variant was 9qh+ (14.04%) in infertile women. Although the rate of polymorphism 9qh+ was higher in the case group compared to the control group, the difference was found to be insignificant. CONCLUSIONS: Although findings regarding the existence of a possible relationship between infertility and chromosomal polymorphisms have been obtained, it is necessary to increase the number of samples and conduct studies using new technologies with a large capacity in order to reveal this relationship more clearly.
Authors and Affiliations
Saliha Handan YILDIZ Yakup Melik ŞENER Nermin AKÇALI Müjgan ÖZDEMİR ERDOĞAN Mustafa YILDIZ
Keywords
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- EP ID EP722636
- DOI https://doi.org/10.18229/kocatepetip.1082713
- Views 34
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