ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF CAPECITABINE IN BULK BY RP-HPLC METHOD
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 3
Abstract
A simple, rapid and selective RP-HPLC method has been developed for quantification of Capecitabine from bulk drug using a mobile phase consisting mixture of methanol and buffer (70:30) (v/v) at the flow rate of 1.0 ml/min. A Phenomenex C18 (250×4.6mm, 5µ particle size) column was used as stationary phase. The retention time for Capecitabine was 4.1min. Linearity was observed in the concentration range of 10 to 50 µg/ml, with good linearity response greater than 0.997. The mean % recovery obtained is 99.996%. The proposed method is precise, accurate, selective and rapid for the determination of Capecitabine in bulk.
Authors and Affiliations
Anjum Fathima , Radhika Tangadpally , Rajani Kondepudi , Ajitha Makula
Keywords
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