ANESTHETIC EFFICACY OF COMBINATION OF TWO PERCENT LIDOCAINE WITH 1:80,000 EPINEPHRINE AND 0.5 MOL/L MANNITOL FOR INFERIOR ALVEOLAR NERVE BLOCKS IN PATIENTS WITH SYMPTOMATIC IRREVERSIBLE PULPITIS: AN IN VIVO STUDY
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2013, Vol 4, Issue 8
Abstract
The purpose of this prospective randomized single blind study was to determine the anesthetic efficacy of combination of 2 % Lidocaine with 1 : 80,000 Epinephrine and 0.5 mol / L Mannitol in Inferior Alveolar Nerve (IAN) Blocks in patients with symptomatic irreversible pulpitis. 60 subjects randomly received IAN Blocks using the following two anesthetic formulations: one formulation comprised of 2.5 ml of 2 % Lidocaine with 1 : 80,000 Epinephrine and the other formulation comprised of 1.6 ml of 2 % Lidocaine with 1 : 80,000 Epinephrine and 0.9 ml of 0.5 mol / L Mannitol. The pain response of the patient was recorded on endodontic access and initial instrumentation using the Heft-Parker Visual Analogue Scale. From the statistical analysis obtained following this study the addition of 0.5 mol / L Mannitol to lidocaine with epinephrine formulations significantly improved effectiveness in achieving a greater percentage of total pulpal anesthesias compared with a lidocaine formulation without Mannitol for IAN blocks. There is a significant improvement in the efficacy of IAN blocks when 2 % Lidocaine with 1 : 80,000 Epinephrine is administered in combination with 0.5 mol / L Mannitol. Based on the results of this study we can conclude that this combination of local anesthetic should be used on a regular basis to obtain successful anesthesia. However there is a need for more research as there are very few studies done on this aspect.
Authors and Affiliations
P. B. Thimmaiah. , Mithra. Hegde , Ganesh. Bhat , Aditya Shetty , Shishir Shetty
Keywords
Related Articles
- EP ID EP120490
- DOI 10.7897/2230-8407.04831
- Views 108
- Downloads 0
TRAPA NATANS (WATER CHESTNUT): AN OVERVIEW
Trapa natans (water chestnut), commonly known as singhara in India, belonging to family Trapaceae, is a free-floating plant which grows in shallow water fields, ponds or swampy land. The water chestnut is native to Europ...
RP- HPLC METHOD FOR SIMULTANEOUS ESTIMATION OF MONTELUKAST SODIUMAND DESLORATIDINE FROM BULK AND TABLETS FORMULATION
A simple, rapid, accurate, precise and validated High performance Liquid Chromatographic method for the simultaneous estimation of Desloratidine(DES) and Montelukast sodium(MON) in bulk and Multicomponant formulation. Th...
IN VITRO AND IN VIVO EVALUATION OF THE GASTRORETENTIVE FLOATING DOSAGE FORM
The aim of the present investigation was to develop and optimize gastro retentive floating system of Pantoprazole for the efficient treatment of acid related disorders and H. Pylori infections. Floating tablets were deve...
PHARMACOGNOSTICAL AND PHYTOCHEMICAL EVALUATION OF PIPER LONGUM L. SPIKE OBTAINED FROM TISSUE CULTURE AND NATURAL HABITAT: A COMPARATIVE STUDY
Piper longum L. is a slender perennial climber used in Ayurveda particularly for respiratory tract disorders. Both spikes and roots of this plant are said to have medicinal value. Over the years, industrial demand of Pip...
VALIDATED HPTLC METHOD OF ANALYSIS OF NIMESULIDE IN BLOOD AND TISSUE DISTRIBUTION IN DIFFERENT ORGANS OF RATS
Nimesulide, (4-nitro-2-phenoxymethane-sulfoanilide), a NSAID compound has been used in human and veterinary medicine having a selective cyclooxygenase-2 (COX-2) inhibition. Besides its potential anti-inflammatory effect,...