Anthelmintic Activity of Ethanol Extract of Polygonum minus Leaves against Ascaridia galli
Journal Title: Journal of Microbiology and Infectious Diseases - Year 2018, Vol 8, Issue 1
Abstract
Objectives: Helminth infection is one of the main matters that cause health problems in developing countries. Polygonum minus are empirically used as an anthelmintic drug, but there has been no scientific study that proves it. Methods: This study was aimed at determining the anthelmintic activity of ethanol extract of Polygonum minus leaves against Ascaridia galli in vitro. The extract was prepared in three different concentrations i.e 0.5 mg/mL, 1 mg/mL and 2 mg/mL. NaCl 0.9% was used as a negative control group and albendazole 0.2 mg/mL, a broad spectrum anthelmintic was used as a positive control group. Ascaridia galli was used as the test parasite. The study involved the determination of death time of the worms. Results: The death time of the worms that caused by the extract concentration 0.5 mg/mL, 1 mg/mL and 2 mg/mL, respectively were (mean±SD) 35±3.32 hours, 32.8±2.39 hours and 25±3.39 hours. The death time that caused by negative and positive control group were 76.6±8.30 hours and 19.2±1.48 hours. There is no significant difference of death time of the worms between the extract concentration 2 mg/mL and the positive control group. Conclusion: The anthelmintic activity of ethanol extract of Polygonum minus leaves has been confirmed and extract concentration 2 mg/mL has the same anthelmintic activity with albendazole 0.2 mg/mL. J Microbiol Infect Dis 2018; 8(1):23-26
Authors and Affiliations
Dara Agusti Maulidya, Muhammad Ibnu Kahtan, Diana Natalia, Mitra Handini, Ari Widiyantoro
Keywords
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- EP ID EP422950
- DOI 10.5799/jmid.403142
- Views 138
- Downloads 0
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Anthelmintic Activity of Ethanol Extract of Polygonum minus Leaves against Ascaridia galli
Objectives: Helminth infection is one of the main matters that cause health problems in developing countries. Polygonum minus are empirically used as an anthelmintic drug, but there has been no scientific study that prov...