Abstract

Objective: To evaluate anthelmintic potential of Helicteres isora (H. isora) bark extract in Indian adult earthworms. Methods: The H. isora bark and Indian adult earthworms (Pheretima posthuma) were collected and authenticated by approved taxonomist. Earthworms were grouped and treated with extract at concentration of 10, 20 and 50 mg/mL, albendazole of 10 mg/mL as standard and normal saline as a control. The paralysis time and death time was considered as indicator of anthelmintic activity. Results: All the extracts showed concentration dependent activity but significant activity was observed at 50 mg/mL. The extract showed better activity at concentration of 50 mg/mL with paralysis time (12.54 min) and death time (16.55 min) when compared to standard albendazole. Conclusions: The study revealed that the methanolic extract of H. isora bark have potent anthelmintic activity against Indian adult earthworms.

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