Hepatoprotective activity of Spillanthes acmella Extracts against CCl4- induced liver toxicity in rats
Journal Title: Asian Pacific Journal of Tropical Disease - Year 2012, Vol 2, Issue 0
Abstract
Objective: Hepato protective activity of Spillanthes acmella Extracts (70% ethanol, methanol, ethyl acetate and hexane) were investigated. Methods: Hepatoprotective activity was assessed against CCl4 induced liver intoxication. Results: The extracts were produced concentration dependent percentage protection in the reduction of enzymes (Serum Glutamate Oxaloacetate Transaminase, Serum Glutamate Pyruvate Transaminase, Alkaline phasphatase and Total bilirubin) levels against CCl4 induced liver intoxication in rats. Among all extracts methanol extract showed better activity compare to other extracts with percentage protection of SGOT (84.39%), SGPT (79.04%), ALP (78.15%) and Total bilirubin (80.00%) levels at a dose of 500mg/kg. Conclusions: From the results obtained during the present study it could be concluded that Spillanthes acmella extracts has components that have hepato protective effects.
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- DOI 10.1016/S2222-1808(12)60153-4
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