ANTHELMINTIC SHANKHPUSHPI PELLETS: TASTE MASKING
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2015, Vol 6, Issue 7
Abstract
Shankhpushpi is a highly potent anthelmintic drug having bitter taste. In the formulation for pediatric & geriatric patients the main challenge to the formulator is to mask the taste of obnoxious and bitter drugs without loss of optimal therapeutic activity of the formulation. The main objective of present study was the in vitro evaluation of the taste masking efficiency and anthelmintic activity of shankhpushpi formulation prepared by extrusion-spheronization. Pellets containing high shankhpushpi loadings in Eudragit L-100-55 were prepared by extruder and spheronizer. The taste masking of processed formulation was evaluated in vitro by dissolution method and chromatographic technique, while anthelmintic effect was evaluated by using six adult Indian earthworms and cattle worms. The result of present study indicated that Shankhpushpi for few minutes began the paralysis of earthworm followed by death at the end of 375.5 minutes. Thus, the present study demonstrated that formulated pellets of Shankhpushpi has potent anthelmintic activity and has commercial significance.
Authors and Affiliations
Praful Giradkar
Keywords
Related Articles
- EP ID EP117312
- DOI 10.7897/2230-8407.06796
- Views 121
- Downloads 0
PLANTS AND ITS PARTS AS A SOURCE OF ANTI- CANCER COMPOUNDS: A REVIEW
Plant has been used in the treatment of many diseases and now it has shown tremendous potential in the treatment of cancer. Various parts of plant including whole plant, leaves, bark, roots and fruits yield compounds whi...
A REVIEW ON AEGLE MARMELOS: A POTENTIAL MEDICINAL TREE
Since time immemorial, plants and their products have been the primary resource of food and medicines for mankind. Aegle marmelos commonly known as bael (or bel), belonging to the family Rutaceae, is a moderate sized, sl...
ETHNOPHARMACOLOGICAL POTENTIAL OF CALOTROPIS PROCERA: AN OVERVIEW
The herbal medicine occupy distinct position right from ancient period. The plant Calotropis procera is known by different names in different part of the world. It is a wild growing medicinal plant distributed throughou...
HEPATOPROTECTIVE AND ANTI-HEPATOTOXIC ACTIVITIES OF AQUEOUS LEAF EXTRACT OF TACAZZEA BARTERI AGAINST CARBON TETRACHLORIDE INDUCED HEPATOTOXICITY IN ALBINO RATS
The hepatoprotective and anti hepatotoxic effect of Tacazzea barteri was evaluated using carbon tetrachloride (CCL4) induced hepatotoxicity. For the hepatoprotective study, the animals were treated with 200, 400 and 600...
FORMULATION AND ASSESSMENT OF GEMIFLOXACIN MESYLATE OCULAR IN SITU GELLING SYSTEM
In situ gels are one of the most successful means of delivering the drug at ocular site with maximum bioavailability, which undergoes gelation upon instillation as drops into the eye due to physicochemical changes inhere...