HEPATOPROTECTIVE AND ANTI-HEPATOTOXIC ACTIVITIES OF AQUEOUS LEAF EXTRACT OF TACAZZEA BARTERI AGAINST CARBON TETRACHLORIDE INDUCED HEPATOTOXICITY IN ALBINO RATS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2013, Vol 4, Issue 9
Abstract
The hepatoprotective and anti hepatotoxic effect of Tacazzea barteri was evaluated using carbon tetrachloride (CCL4) induced hepatotoxicity. For the hepatoprotective study, the animals were treated with 200, 400 and 600 mg/kg of T. barteri extract for 7 days prior to the intra peritoneal injection of 1 ml/kg of carbon tetrachloride while for the anti hepatotoxic study; 1 ml/kg of carbon tetrachloride was administered via intra peritoneal route before treatment (2 days). Blood samples were collected from the animals before and after treatment and serum biochemical parameters (AST, ALT, ALP, Bilirubin and Albumin) were determined. The extract showed significant (p < 0.01) reduction in the carbon tetrachloride induced elevation of ALT, AST, ALP and Bilirubin and a significant (p < 0.01) increase in carbon tetrachloride induced suppression of Albumin induction in both models. Histological photomicrographs of liver sections of the untreated groups showed high cellular damage while no visible histological damages were noticed in the extract treated groups in the hepato-protective model while mild cellular damage was noticed in the anti-hepatotoxic model. The extract not only showed protection of the liver cells against CCL4 hepatotoxin but also showed reversal of hepatic damage cause by CCL4. This study justifies the folkloric use of T. barteri in the treatment of liver diseases.
Authors and Affiliations
Obioha Quinette Uru, Ilodigwe Emeka, Ajaghaku Lotanna, Umeokoli Ogechukwu
Keywords
Related Articles
- EP ID EP151770
- DOI 10.7897/2230-8407.04913
- Views 106
- Downloads 0
BUOYANT OIL ENTRAPPED CALCIUM PECTINATE GEL BEADS OF FAMOTIDINE
In the present study, Buoyant oil entrapped calcium pectinate gel beads of Famotidine were prepared by emulsion gelation method. Oil entrapped calcium pectinate gel beads concept was applied to increase the gastric reten...
RECOVERY PROCESS OF SALICYLIC ACID FROM LAMIVUDINE AND REDUCING ITS IMPACTS ON ENVIRONMENT BY USING THE RECOVERY AND MANUFACTURING PROCESS
Salicylic acid is used in the manufacturing process of Lamivudine, so far no literature available for recovery salicylic acid in Lamivudine manufacturing process. The present work relates to recovery of salicylic acid fr...
EVALUATION OF HYPOGLYCEMIC AND WOUND HEALING ACTIVITIES OF LANTANA WIGHTIANA WALL. EX GAMBLE LEAVES
Lantana wightiana Wall, a member of Verbenaceae is an unarmed sub shrub, up to 3 m tall. The present study was aimed at evaluating the hypoglycemic and wound healing activities of Lantana wightiana. The leaves were colle...
PHARMACOLOGICAL AND PHARMACEUTICAL PROFILE OF DARUNAVIR: A REVIEW
Treatment of human immunodeficiency virus (HIV) infection involves a combination of several antiviral agents belonging to different pharmacological classes. Darunavir is a second-generation protease inhibitor. It used to...
PRODUCTION, PURIFICATION AND FUNCTIONALIZATION OF CARBON NANOTUBES FOR MEDICAL APPLICATIONS
Carbon nanotubes (CNTs) are needle-like potential carriers of bioactive including drug, genes and proteins. This review considers several techniques that have been developed for fabricating, purifying and functionalizing...