EVALUATION OF HYPOGLYCEMIC AND WOUND HEALING ACTIVITIES OF LANTANA WIGHTIANA WALL. EX GAMBLE LEAVES
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 12
Abstract
Lantana wightiana Wall, a member of Verbenaceae is an unarmed sub shrub, up to 3 m tall. The present study was aimed at evaluating the hypoglycemic and wound healing activities of Lantana wightiana. The leaves were collected, shade dried and extracted with water and ethanol-water (1:1) by maceration for 72h. The aqueous extract was used for anti diabetic activity in both normal and alloxan induced diabetic rats and hydro alcoholic extract along with leaf juice were evaluated for their wound healing activity in Excision wound model. Studies on the aqueous leaf extract of the plant L. wightiana revealed that the extract caused significant reduction in the blood glucose levels in the rats. The extract was found to produce marked reduction in blood glucose concentration between 2-4 hours of administration in alloxan induced hyperglycemic rats at tested dose levels. The studies on wound healing activity revealed that the nitrofurazone treated animals showed 95.19% healing on 14th day of study. On the other hand, the hydro alcoholic extract and leaf juice treated group showed 87.13% and 94.19% healing respectively.
Authors and Affiliations
Srinivas Reddy, Sanjeeva Kumar, S. Ganapaty
Keywords
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- EP ID EP150711
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