OPTOGENETICS: A NOVEL APPROACH IN PACING HAERT TISSUE AND ENGENDER PROPAGATING CARDIAC IMPULSES
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 4
Abstract
The cardiac pacemaker controls the rhythmicity of heart contractions and these can be substituted by battery-operated devices as last resource. Optogenetics involves insertion of light-sensitive proteins into human embryonic stem cell to encode DNA making mammalian tissues light-sensitive. The first discovered protein of this type is Channelrhodopsin2 (ChR2), which is widely used in neuroscience. The limitation of electrical stimulation of heart, a standard technique can be overcome by using ChR2.The various methods involved in optogenetics and energy needs were discussed in this section. Initially, optogenetics is confined only to neuronal system, later on extended to heart and other organs. This method involves precise localized stimulation and constant prolonged depolarization of cardiomyocytes and cardiac tissue resulting in alterations of pacemaking, Ca2+ homeostasis, electrical coupling and arrhythmogenic spontaneous extra beats.
Authors and Affiliations
Abhinay Pasam , Victoria Bethapudi , Babu Chandu , Sreekanth Nama , Bhargavi Sakala
Keywords
Related Articles
- EP ID EP92652
- DOI -
- Views 183
- Downloads 0
SYNTHESIS, DOCKING STUDIES AND ANTIOXIDANT ACTIVITY OF LINEAR TETRAPEPTIDE FAYV
The linear tetrapeptide Phe-Ala-Tyr-Val (FAYV) was designed based on docking results using Schrodinger Software tool. The tetrapeptide was conveniently synthesized by solution phase peptide synthesis using Dicyclohexylca...
DEVELOPMENT AND VALIDATION OF UV SPECTROSCOPIC METHOD FOR THE ESTIMATION OF AQUEOUS EXTRACT OF FAGONIA SCHWEINFURTHII HADIDI
A simple, rapid, accurate, precise, and economic spectrophotometric method for aqueous extract of Fagonia schweinfurthii hadidi have been developed. Aqueous extract of plant was obtained from decoction process of coarse...
IN-VITRO STUDY OF ENTAMOEBA HISTOLYTICA WITH COCONUT JUICE ACT AS AN ANTIAMOEBIC AGENT AT DIFFERENT CONCENTRATION IN NIH MEDIUM
Amoebiasis is a parasitic infection caused by Entamoeba histolytica. It is usually contracted by ingesting water or food contaminated with amoebic cysts. Amoebiasis is an intestinal infection that may or may not be sympt...
NOVEL ANALYTICAL METHOD FOR IMPROVEMENT OF AQUEOUS SOLUBILITY OF CANDESARTAN CILEXETIL USING CO-SOLVENCY APPROACH
The present study was aimed at improving the aqueous solubility of candesartan cilexetil, a poorly water soluble drug, using poly ethylene glycol (PEG) 400 as co-solvent. It was observed that use of 5 % PEG 400 as co-sol...
CONFIRMATION AND ESTIMATION OF CHLORAMPHENICOL RESIDUES IN GALDA (MACROBRACHIUM ROSENBERGII) BY ULTRA PERFORMANCE LC® (UPLC) AND MS/MS (TQD) SYSTEM
An Ultra performance liquid chromatography – tandem quadrupole mass spectrometry (UPLC–MS/MS) method was developed for the determination of chloramphenicol in Galda shrimp (Macrobrachium rosenbergii). The UPLC separation...