RECOVERY PROCESS OF SALICYLIC ACID FROM LAMIVUDINE AND REDUCING ITS IMPACTS ON ENVIRONMENT BY USING THE RECOVERY AND MANUFACTURING PROCESS
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2012, Vol 3, Issue 4
Abstract
Salicylic acid is used in the manufacturing process of Lamivudine, so far no literature available for recovery salicylic acid in Lamivudine manufacturing process. The present work relates to recovery of salicylic acid from Lamivudine manufacturing process. It was obtained as a byproduct, combination of Ethyl acetate and Triethyl amine containing salicylates. Recovery of Salicylic acid from Lamivudine is a new treatment for Ethyl acetate and Triethyl amine which contains salicylic acid, which is difficult to treat using biological effluent treatment processes. The brief description of proposed recovery of salicylic acid process is, by distillation of mass and eliminate the Ethyl acetate and Triethyl amine. After distillation the remaining mass is filtered in water and carbon media, which on further treatment with Hydrochloric acid, adjust the pH up to 1-2 and then filter the mass and dry it gives result of white crystalline salicylic acid recovery. This process offers particular advantages in term of swiftness, high efficiency, cost reduction and chemical waste reduction in Lamivudine manufacturing process. It is a recyclable and eco-friendly recovery process. The aim of the present study was recovery of the salicylic acid in Lamivudine manufacturing process and reducing its impacts on environment. Experiments were carried out at batch and tests in order to investigate equilibrium and dynamic condition of salicylic Acid recovery process.
Authors and Affiliations
Srinivasa Babu, Arbindasahu , Mukkanti , Sadineni Rao, B. N. Murthy
Keywords
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