Anthracyclines: etiopathogenic basis of their cardiotoxicity
Journal Title: Revista Científica Estudiantil de Ciencias Médicas de Matanzas - Year 2022, Vol 1, Issue 2
Abstract
Cancer is a serious health problem of humanity, although there is currently an increase in expectations of a cure thanks to therapeutic advances and they are anthracyclines are undoubtedly the most widely prescribed cytotoxic agent despite their cardiotoxicity of 5% to 23% of cases. The present literature review aimed toexplain the etiopathogenic mechanisms of anthracyclines in the genesis of cardiotoxicity. For this, a total of 22 bibliographic sources were consulted, including articles from magazines, books and others, accessed through the main information managers. It was concluded thatanthracycline-induced cardiotoxicity is due to different mechanisms that are related to each other, these are the production of free radicals, defects in mitochondrial structure and function, alteration in calcium and iron homeostasis and alteration in gene expression.
Authors and Affiliations
Diana Laura GarcÃa-Guirola,Diana Laura GarcÃa-Pérez,Mario Miguel Gómez-RodrÃguez,Dailly Peraza-Pons,
Keywords
Related Articles
- EP ID EP741848
- DOI -
- Views 12
- Downloads 0
Some clinical aspects of pneumonia associated with mechanical ventilation
Introduction: Emergency services in hospitals worldwide have advanced over the years by implementing new techniques to solve respiratory problems in older adult patients. These respiratory problems are an important cause...
Tissue engineering: achievements and future projections
En la actualidad se conoce como IngenierÃa Tisular o de Tejidos a la rama de la IngenierÃa Biomédica, que se enfoca en reparar, mantener, reemplazar y mejorar la función de tejidos u órganos afectados por enfermed...
Characterization of families where older adults live in Canambua neighborhood, Malanje, 2022
Introduction: the family constitutes the first social support network that the individual possesses throughout life. Aging is a constant in life, but it acquires relevance in public health due to the demographic changes...
History of immunology in Cuba and its main contributions as a science
Introduction: the discipline of immunology emerged when it was observed that individuals recovered from certain infectious disorders were later protected against the disease. Objective: describe the history of immunolog...
Assisted reproduction. Past, present and future in the Bioethics debate
Assisted reproductive techniques provided a solution to one of the most distressing medical problems: infertility, but at the same time they implied multiple problems from the bioethical point of view during its scientif...