Anti-allergic drugs and the Annexin-A1 system.
Journal Title: Pharmacological Reports - Year 2010, Vol 62, Issue 3
Abstract
This paper, which was presented at the 17th JMRC 'John Robert Vane Memorial' Symposium, describes some recent work from the authors' laboratory that provides a tentative explanation for the anti-inflammatory effects produced by the cromoglycate-like anti-allergic drugs. Some of the implications of this finding are discussed.
Authors and Affiliations
Samia Yazid, Samir Ayoub, Egle Solito, Simon McArthur, Phuong Vo, Neil Dufton, Roderick Flower
Keywords
Related Articles
- EP ID EP102481
- DOI -
- Views 68
- Downloads 0
Role of potassium channels in the relaxant effect of levosimendan in guinea pig tracheal preparations.
We investigated both the effect of levosimendan and the role of various potassium channels in carbachol-precontracted tracheal preparations samples obtained from guinea pig. The tracheas were cut into 0.5 cm wide rings a...
Mechanisms of [Ca(2+)]i elevation following P2X receptor activation in the guinea-pig small mesenteric artery myocytes.
Background: There is growing evidence suggesting involvement of L-type voltage-gated Ca(2+) channels (VGCCs) in purinergic signaling mechanisms. However, detailed interplay between VGCCs and P2X receptors in intracellula...
Effects of catecholamines on blood pressure in the femoral bone marrow cavity in ovariectomized rats.
Menopausal women display changes in the osseous tissue (osteoporosis, pathologic fractures) and disorders in the function of cardiovascular system (hypertension, cardiovascular disease, arteriosclerosis, calcification)....
Influence of paraquat on dopaminergic transporter in the rat brain.
Selective toxicity of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP),a parkinsonism inducing compound, is well known to be related to an uptake of its active metabolite MPP(+)into dopaminergic neurons by dopamine tr...
Buspirone improves 6-hydroxydopamine-induced catalepsy through stimulation of nigral 5-HT(1A) receptors in rats.
Receptors for 5-HT(1A) are widely distributed throughout the basal ganglia, and their activation results in an inhibition of dopamine (DA) release. This study aimed to investigate the effect of buspirone, as a partial ag...