Effects of catecholamines on blood pressure in the femoral bone marrow cavity in ovariectomized rats.
Journal Title: Pharmacological Reports - Year 2006, Vol 58, Issue 6
Abstract
Menopausal women display changes in the osseous tissue (osteoporosis, pathologic fractures) and disorders in the function of cardiovascular system (hypertension, cardiovascular disease, arteriosclerosis, calcification). Additionally, interdependence was observed between the loss of osseous tissue and disordered circulation, but the mechanism of the interdependence has never been fully recognized. In order to clarify this problem, the present study concentrated on the effects of catecholamines on blood pressure in the femoral bone marrow cavity in ovariectomized rats. The Ficat-Arlet method was used to examine blood pressure in marrow cavity. Norepinephrine, epinephrine, isoprenaline as well as adrenoceptor antagonists (phentolamine and propranolol) were administered to the controls and the ovariectomized rats. The examinations demonstrated that ovariectomized rats displayed decreased blood pressure in the marrow cavity. In addition, an intensified effect of catecholamines on blood pressure in the marrow cavity of osteoporotic bone in ovariectomized rats was observed.
Authors and Affiliations
Ilona Kaczmarczyk-Sedlak, Urszula Cegieła, Barbara Nowińska, Maria Pytlik
Keywords
Related Articles
- EP ID EP91205
- DOI -
- Views 79
- Downloads 0
Modified C-reactive protein interacts with platelet glycoprotein Ibα.
Herein, we investigated the possible mechanisms by which recombinant modified CRP(m(r)CRP) modulates blood platelet function. Modified CRP could activate blood platelets and stimulate their adhesion and aggregation in th...
Overview on 5-HT receptors and their role in physiology and pathology of the central nervous system.
The present review gives an overview on the serotonin (5-hydroxytryptamine; 5-HT) system, its receptors and their relationship to central nervous system physiology and disorders. Additionally, we also introduce the recen...
Evaluation of the antioxidative properties of lipoxygenase inhibitors.
Background: Oxidative stress is a component of many pathological conditions including neurodegenerative diseases and inflammation. An important source of reactive oxygen species (ROS) are lipoxygenases (LOX) - enzymes re...
Macrophages and depression - a misalliance or well-arranged marriage?
Depression is a severe medical condition with multiple manifestations and diverse, largely unknown etiologies. The immune system, particularly macrophages, plays an important role in the pathology of the illness. Macroph...
Aspirin-induced asthma: a tribute to John Vane as a source of inspiration.
Aspirin-induced asthma is a distinct clinical syndrome consisting of inflammation, characterized by chronic eosinophilic rhinosinusitis with asthma and often nasal polyposis. Aspirin and other nonsteroidal anti-inflammat...