Effects of catecholamines on blood pressure in the femoral bone marrow cavity in ovariectomized rats.
Journal Title: Pharmacological Reports - Year 2006, Vol 58, Issue 6
Abstract
Menopausal women display changes in the osseous tissue (osteoporosis, pathologic fractures) and disorders in the function of cardiovascular system (hypertension, cardiovascular disease, arteriosclerosis, calcification). Additionally, interdependence was observed between the loss of osseous tissue and disordered circulation, but the mechanism of the interdependence has never been fully recognized. In order to clarify this problem, the present study concentrated on the effects of catecholamines on blood pressure in the femoral bone marrow cavity in ovariectomized rats. The Ficat-Arlet method was used to examine blood pressure in marrow cavity. Norepinephrine, epinephrine, isoprenaline as well as adrenoceptor antagonists (phentolamine and propranolol) were administered to the controls and the ovariectomized rats. The examinations demonstrated that ovariectomized rats displayed decreased blood pressure in the marrow cavity. In addition, an intensified effect of catecholamines on blood pressure in the marrow cavity of osteoporotic bone in ovariectomized rats was observed.
Authors and Affiliations
Ilona Kaczmarczyk-Sedlak, Urszula Cegieła, Barbara Nowińska, Maria Pytlik
Keywords
Related Articles
- EP ID EP91205
- DOI -
- Views 119
- Downloads 0
Vascular prostaglandin synthesis: the early days.
Prostacyclin (PGI(2)) and thromboxane (TxA(2)) labile cyclooxygenase (COX) products via PGH(2) were identified in biological fluids by the ingenious application of the principle of parallel pharmacological assays develop...
Reason for the aggravation of diseases caused by inflammation and the ineffectiveness of NSAIDs on these diseases in rainy weather.
In this study, the anti-inflammatory activity of indomethacin, diclofenac, meloxicam and nimesulide were investigated on sunny and rainy days. Parallel to these experiments, the question of whether endogenous adrenaline...
Fluvastatin does not elevate periosteal osteogenesis induced by Moloney sarcomavirus (MSV) in mice.
Several studies have demonstrated the pleiotropic effects of statins. Since Wang and associates reported that in rabbits lovastatin reduced steroid-induced bone loss, numerous authors have confirmed these data, however,...
Cannabinoid CB1 receptors in rat medial prefrontal cortex are colocalized with calbindin- but not parvalbumin- and calretinin-positive GABA-ergic neurons.
In the present study, we investigate putative localization of cannabinoid receptors 1 (CB1) protein on a population of cortical gamma-aminobutyric acid (GABA) - positive interneurons characterized by expression of calciu...
Role of phosphoinositide 3-kinase in ischemic postconditioning-induced attenuation of cerebral ischemia-evoked behavioral deficits in mice.
The present study has been designed to pharmacologically investigate the role of phosphoinositide 3-kinase in ischemic postconditioning-induced reversal of global cerebral ischemia and reperfusion-induced behavioral dysf...