Anti-Anemic activity of Hydro-alcoholic extract of Calotropis procera flower on phenylhydrazine- induced anaemic rats
Journal Title: IP International Journal of Comprehensive and Advanced Pharmacology - Year 2017, Vol 2, Issue 1
Abstract
The present study was to evaluate the anti-anaemic activity of Calotropis procera flower of Apocynaceae family. Anemia was induced in rats by intra-peritoneal administration of phenylhydrazine at the dose of 40 mg / kg / day for two days. Hydroalcoholic extract was given orally to anaemic rats at 100 mg/kg and 200 mg / kg body weight, once a day for 28 days. Blood samples were collected from the rats by tail incision on days D0, D2, to the 1st, 2nd, 3rd and 4th week of treatment and subjected to the analysis of red blood cells (RBC), hemoglobin (Hb) and hematocrit (PCV). Extracts at dose of 100mg/kg and as well 200 mg / kg increased (p <0.001) significantly the number of red blood cells in the 4th week of treatment when compared with that untreated anaemic group. In addition, the hemoglobin level increased (p<0.01) significantly in the first week of treatment to the rats of groups III and IV which received respectively reference antianaemic (Vitamin B12). The anti-anemic effect of Hydroalcholic aqueous extract was comparable to that of the drug Vitamin B12.
Authors and Affiliations
Kushwaha Hariom, Ankur Joshi, Sapna Malviya, Anil Kharia
Keywords
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Anti-Anemic activity of Hydro-alcoholic extract of Calotropis procera flower on phenylhydrazine- induced anaemic rats
The present study was to evaluate the anti-anaemic activity of Calotropis procera flower of Apocynaceae family. Anemia was induced in rats by intra-peritoneal administration of phenylhydrazine at the dose of 40 mg / kg /...
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