Improvement in lipid profile of the patients with saxagliptin as add on therapy to metformin in patients of type 2 DM who were previously on metformin alone with uncontrolled diabetes
Journal Title: IP International Journal of Comprehensive and Advanced Pharmacology - Year 2018, Vol 3, Issue 1
Abstract
Introduction Diabetes is characterized by chronic hyperglycemia and disturbances of carbohydrate lipid and protein metabolism This study is an attempt to show an improvement in lipid profile TC TG LDL and HDL in patients of type 2 diabetes mellitus who were previously on metformin monotherapy with uncontrolled diabetesMaterial and method A total of 30 patients were enrolled who were on metformin monotherapy and with uncontrolled diabetes Patients were given metformin 500 mg twice a day and saxagliptin 25 mg once a dayPatients were followed up at 1st 3rd and 6th month and lipid profile TC TG LDL and HDL estimation was done during the follow up periodResults The mean age plusmn SD in male and female patients was 6142 yrs plusmn 699 and 5593 yrs plusmn 574 respectively The mean change in value from baseline at 24 weeks was TC 966 TG 940 LDL 1487 HDL 563 A highly significant difference has been seen at 0 vs 1 0 vs 3 and 0 vs 6 months in TC TG LDL and HDL valuesConclusion Saxagliptin has shown an improvement in lipid profile TC TG LDL HDL during 6 months of treatment in patients of type 2 DMKeywords Saxagliptin Uncontrolled type 2DM Metformin Lipid profile
Authors and Affiliations
Akshay Dahiwele, Dinesh Kansal, Dheeraj Kapoor, Parveen Sharma
Keywords
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- EP ID EP481702
- DOI 10.18231/2456-9542.2018.0003
- Views 84
- Downloads 0
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