Extemporaneous compounding: Cautions, controversies and convenience
Journal Title: IP International Journal of Comprehensive and Advanced Pharmacology - Year 2018, Vol 3, Issue 4
Abstract
Pharmacists are only knowledgeable and skilled healthcare professionals dedicated to compounding and preparing medications to meet the unique needs of patients The safe and effective extemporaneous compounding of prescription products for patients require in special care is fundamental to the pharmacy profession But there are much to do for secundum artem It is not at all economical for a pharmaceutical company to marketize a product in 10 different probable doses or in 5 different dosage forms to meet the needs of the entire range of individuals receiving therapy Although development is a continuous process companies are customizing features to meet the majority of patient needs but the very nature of the process cannot meet all patient needs The riskbenefit ratio of using traditionally compounded medicines is favorable for patients who require specialized medications that are not commercially available as they would otherwise not have access to suitable treatment However if an FDAapproved drug is commercially available the use of an unapproved compounded drug confers additional risk with no commensurate benefit Published reports of independent testing by the FDA state agencies and others consistently show that compounded drugs fail to meet specifications at a considerably higher rate than FDAapproved drugs Compounded sterile preparations pose the additional risk of microbial contamination to patients In the last 11 years three separate meningitis outbreaks have been traced to purportedly sterile steroid injections contaminated with fungus or bacteria which were made by compounding pharmacies The 2012 outbreak has resulted in intense scrutiny of pharmacy compounding practices and increased recognition of the need to ensure that compounding is limited to appropriate circumstancesPurpose of The Study The article intends to physicochemical and economic contemplations previously compounding elements and quality control issues compounding support preparing chemical supplies kinds of compounding exceptionally in hospital and walking care compounding It should help to rehearse the unpremeditated readiness of fundamental and propelled definitions including pharmacopoeial and nonpharmacopoeial plans experienced in drug store practice together with essential documentation marking bundling and directing prerequisites Alongside this they need to contemplate the investigation of definitions and their segments and relate these to the clinical execution of medicines This will assist them with investigating assess and report the physical attributes of details including discharge energy and relate these to quality control and preformulation prerequisites relate the utilization of quality control quality confirmation and the standards of good assembling practice to direction of medicine creation in home and abroadOutline Background Introduction Compounding Factors Types of Compounding Identifying Errors and CauseKeywords Pharmacy practice Drugs Dosage forms Compounding Equipment Pharmacopeia
Authors and Affiliations
A K Mohiuddin
Keywords
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- EP ID EP481743
- DOI 10.18231/2456-9542.2018.0028
- Views 149
- Downloads 0
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