Anti-Apoptotic Gene: Survivin.
Journal Title: International Journal of Dental Science and Innovative Research (IJDSIR) - Year 2019, Vol 2, Issue 2
Abstract
In developing countries where most people live in rural areas, oral cancer tends to be a challenge in diagnosis and management, as most of the cases present at a later stage. Carcinogenesis is a multifactorial process which involves the activation of oncogenes and the inactivation of tumour suppressor genes. Biomarkers are important in establishing an accurate diagnosis and also can provide prognostic data. Survivin is a member of the inhibitor of apoptosis (IAP) protein family that inhibits caspases and blocks cell death, is highly expressed in most cancers and is associated with a poor clinical outcome. It orchestrates several important mechanisms to support cancer cell survival including inhibition of apoptosis and regulation of cell division. These feature makes survivin an ideal target for cancer therapy. The present review focuses on role of survivin cancerous and pre-cancerous lesions of oral cavity.
Authors and Affiliations
Dr. S. R . K. Nandan
Keywords
Related Articles
- EP ID EP577295
- DOI -
- Views 89
- Downloads 0
Arginase: An Emerging Key Player in Periodontal Disease and Diabetes Mellitus.
Introduction: Arginase is a semi-essential amino acid, an enzyme found in saliva which is involved in inflammation.Arginase is found mainly in the human liver, also found in salivary glands. Saliva is an important biolog...
Maxillary Arch Width And Buccal Corridor Width And Area Changes In Class I Extraction Cases.
Aims and Objectives: To compare the pre-treatment and post-treatment maxillary arch width and buccal corridor changes in class I malocclusion treated with four premolar extraction Methods: pretreatment and post treat...
The use of customized trainers in Class II division 1 malocclusion.
The class II division 1 malocclusions, in growing patients, are usually associated to functional disorders. The treatment plan of these malocclusions must include the treatment of oro-facial dysfunc...
Mandibular Canine Index as a Tool for Sex Determinant.
Objective: Various methods are used for gender identification in forensic investigations. The canine tooth is widely used for gender determination because of its sexual dimorphism and durability in the oral cavity. Mandi...
Oral Malignant Melanoma: a case report.
Oral malignant melanoma is a very rare malignancy with unknown etiology. It is mostly seen in mid age group. A localization of oral melanoma was highly found in the maxillary gingival and palate. Gender prediliction was...