Anti-Cancer Therapy: Chlorogenic Acid, Gallic Acid and Ellagic Acid in Synergism

Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2017, Vol 12, Issue 3

Abstract

Phytochemicals have been used as effective agents for treating illnesses. Its use has been widely increased in the present scenario where commercial drugs are carrying a huge burden of side effects. Many phytochemicals have potent anticancer properties. The present study was undertaken to study the synergistic effect of anticancer phytochemicals Chlorogenic acid, Gallic acid and Ellagic acid on MDA MB 231 Breast cancer cells. The study was evaluated using cytotoxic assay such as MTT assay and migration assay via scratch well assay. The results demonstrate that the selected phytochemicals are highly cytotoxic to the cells and thus, synergistic studies were performed and the most cytotoxic combinations were proceeded with further assay which reveals that there is no migration observed in the presence of selected phytochemical combinations, thus revealing that treatment must be anti-metastatic.

Authors and Affiliations

Archana Moon1 ,, Trupti Agrawal2, Pooja Gupta3, Nikita Kondlekar4 ,, Amit Taksande5

Keywords

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  • EP ID EP389770
  • DOI 10.9790/3008-1203064852
  • Views 89
  • Downloads 0

How To Cite

Archana Moon1, , Trupti Agrawal2, Pooja Gupta3, Nikita Kondlekar4, , Amit Taksande5 (2017). Anti-Cancer Therapy: Chlorogenic Acid, Gallic Acid and Ellagic Acid in Synergism. IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS), 12(3), 48-52. https://europub.co.uk/articles/-A-389770