Biosynthesis of Iron Oxide Nanoparticles using Aqueous Extract of Convolvulus Pluricaulis Plant, its Characterization and Acute Oral Toxicity Studies
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2017, Vol 12, Issue 3
Abstract
The synthesis of nanoparticles by green approach has been of great interest because of its ecofriendly and non-toxic potential in biomedical applications. The present study was aimed to synthesize Convolvulus pluricaulis iron oxide nanoparticles (CPIO) using its aqueous extract. The phytochemicals available in the aqueous extract acted as effective reducing agent and capping agent. The CPIO nanoparticles synthesized were characterized by PSA, XRD, FTIR, SEM and TEM. FTIR measurements showed the CPIO nanoparticles having a coating of phytochemical compounds indicating a possible role of biomolecules from Convolvulus pluricaulis for capping and efficient stabilization of the CPIO nanoparticles. The XRD spectrum confirmed the crystalline structure of CPIO nanoparticles with an average particle size of 32.8nm .The synthesized CPIO nanoparticles are found to be agglomerated porous nanoparticles from the SEM and TEM images. Acute oral toxicity studies were carried out for a period of 14 days and no mortality was observed during this treatment period. As no synthetic reagents were used in this method, the synthesized CPIO nanoparticles are non-toxic, biocompatible so have potential biomedical applications.
Authors and Affiliations
Lakshmi Pravallika Poka, Krishna Mohan G1 ,, Venkateswara Rao K2 ,, Shanker K1
Keywords
Related Articles
- EP ID EP389317
- DOI 10.9790/3008-1203046975
- Views 91
- Downloads 0
Evaluating the Effect of PIH on Rats-Liver Overloaded with Iron
The accumulation of iron (Fe) in the liver is a serious complication of thalassemia and other ironloading anemias requiring long-term blood transfusions. Such patients are directed to suffer death unless they are treated...
Test of Effectiveness of Thorny Palm Skin (Salacca Edulis) and Noni Extract (Morinda Citrifolia L) On Decreasing the Blood Sugar Rate Of Male Mice (Mus Musculus)
This research is meant to know the effectiveness of thorny palm skin (Salacca edualis) and noni (Morinda citrifolia L) extract on the decrease of mice’ blood sugar level (Mus musculus L.). The experimental animals used w...
Bacteriuria in Pregnant and Non Pregnant Women in Benghazi Acomparative Study
Background: Bacteriuria is associated with significant maternal and foetal risks. However, its prevalence is not well known in our community. Objectives: Determine the prevalence and predictors of bacteriuria in women of...
Analgesic, Antiinflammatory Activity of Tinospora Cordifolia (Guduchi) and Valeriana Wallichi (Tagara) In Albino Rats
Objectives: The present study was carried out 1) To evaluate analgesic and anti-inflammatory activity of T.Cordifolia and V.Wallichi in albino rats. 2) To compare the analgesic and anti-inflammatory activity of T.cordifo...
Assessment Of The Indoor And Outdoor Mycoflora Of Schools In Jabalpur City, India
A survey for viable fungal spores in the indoor and outdoor environments of 60 school buildings in Jabalpur city was carried out with two-stage Anderson sampler from January to December, 2010. Air was sampled monthly at...