The effect of ethanolic extract of Tridaxprocumbens on potassium bromate induced hepatotoxicity in adult wistar rats.
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2018, Vol 13, Issue 6
Abstract
The toxic effect of potassium bromate on humans has drawn so much attention due to toxicity being related to some vital organs like the kidney and liver. However, numerous medicinal plants contain biologically active compounds that have shown to be useful in improving the life and treatment of diseases.This study seeks to assess the effect of ethanolic extract of Tridaxprocumbenson potassium bromate induced hepatotoxicity in adult wistar rats.Twenty (20) adultwistar rats weighing between 180 – 200g were divided into four groups of five rats each. Group A was the control and was administered distilled water only for 14 days, Group B were administered 100mg/kg of potassium bromate only for 14 days, Group C 300mg/kg of Tridaxprocumbens leaf extract only for 14 days and Group D 100mg/kg of potassium bromate only for 7 days prior to treatment with 300mg/kg of ethanolic extract of Tridaxprocumbens for 7 days. Twenty four hours after the last administration, the animals were anaesthetized, sacrificed and the livers harvested. The dry mass of the extract was used for preliminary phytochemical analysis. The preliminary phytochemical analysis of ethanolic extract of the leaf of Tridaxprocumbensindicated the presence of flavonoids, alkaloids, saponins, tannins, terpenes, phenolic compounds and cardiac glycosides. Histological observation showed restoration of the liver architecture to normal after treatment with Tridaxprocumbens. Findings from this study show that ethanolic extract of Tridaxprocumbens leaf has got hepatoprotective effect against potassium bromate induced hepatotoxicity.
Authors and Affiliations
Opara Julia K, Ewa Ogbonnaya, Oraebosi Michael I, Agbai Johnson U, UcheIfeoma U
Keywords
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- EP ID EP428742
- DOI 10.9790/3008-1306026266.
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