Exploring Moringa Oleifera Usefulness In Ameliorating Induced Retinopathy In Experimental Animals
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2017, Vol 12, Issue 5
Abstract
Retinopathy is a major problem of vision. It could lead to loss of vision. It is simply the degeneration of the retina. This can be as a result of assault or trauma to the eye or its retina. It can also be as a result of complications of health including diabetes. A totally damaged retina is an indication of total loss of visual perception, which also implies total loss of vision. It is however helpful to prevent the retina from degenerating. This experiment is an attempt to explore the potentials of the phytochemicals of Moringa oleifera [moringa] in its ethanolic extract to ameliorate retina degeneration caused by sodium iodate [NaIO3] toxicity. Twenty four adult male animals weighting between 180 and 200g were divided into Groups A-D. Group A animals served as the Control group; they were only fed ad libitum. Group B animals were administered 50mg/kg body weight of sodium iodate [NaIO3] through the tail vein to induce retinpathy. Group C animals were administered sodium iodate [NaIO3, 50mg/kg BW] once to induce retinopathy and thereafter administered a daily dose of a low dose of the ethanoic extract of moringa [200mg/kg BW] daily with an oral cannula.Group D animals were admisnitred sodium iodate once [NaIO3, 50mg/kg BW] to induce retinopathy and therefater a high dose of the ethanoic extract of moringa [500mg/kg BW] daily, with an oral cannula. Moringa administration lasted ten days after animals were injected [NaIO3]. Results incidate that the NaIO3-induced retinoathy was only fairly ameliorated by moringa extract.
Authors and Affiliations
1Owolabi Joshua O*, Olatunji Sunday Y, 1, Olanrawaju John A, 1 Ishmael Temitope Z
Keywords
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- EP ID EP391127
- DOI 10.9790/3008-1205032129
- Views 63
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