Anti-diabetic activity of Jasminum trichotomum aerial parts methanolic extract in alloxan induced diabetic rats
Journal Title: International Journal of Research in Pharmacology & Pharmacotherapeutics (IJRPP) - Year 2014, Vol 3, Issue 4
Abstract
The aim of this study is to evaluate the anti-diabetic activity of the methanolic extract of jasminum trichotomum aerial parts in albino wistar rat models. The methanolic extract of jasminum trichotomum aerial parts was prepared by using methanol 48 hrs in Soxhlet’s extraction process (continuous hot percolation). The extract was distilled by distillation process and concentrated. In oral dose 100 and 200 mg/kg of the extract was evaluated for anti-diabetic activity in alloxan induced diabetic rats. A blood glucose level of all animals was determined at the 0, 7, 14 and 21 day by using one touch Glucometer by single drop method. The blood parameters and histopathological studies were done. The dosage of 100 and 200 mg/kg of the extract significantly decrease the blood glucose level in diabetic rats. The histopathological study has shown regeneration of β cells at both dose of extract. The obtained results have shown that the Jasminum trichotomum aerial parts of methanolic extract shown that consist of the anti-diabetic activity present.
Authors and Affiliations
Garla Manasa
Keywords
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