Anti-HMGCR Antibody Associated Necrotizing Autoimmune Myopathy-A Case-Based Clinical Review
Journal Title: Journal of Clinical and Medical Research - Year 2019, Vol 1, Issue 1
Abstract
A 54 years gentleman presented with proximal and distal myopathies with a history of statin exposure with persistent symptoms posts statin cessation. CPK ranged from 18000 to 25000 IU/L. Lower limb MRI showed extensive bilateral muscle oedema consistent with myositis. EMG was consistent with an inflammatory myopathic disease. Muscle histopathology revealed evidence of fibers' degeneration and necrosis in the absence of inflammation. Improvement in clinical symptomatology and muscle enzymes showed with pulse steroids and other immunomodulators including Methotrexate, IVIG and Rituximab.
Authors and Affiliations
Aadil Al Ghafri*, Omer Hussein, Trevor Duffy, Eithne Murphy, Maurice Barry
Keywords
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- EP ID EP708365
- DOI https://doi.org/10.37191/Mapsci-2582-4333-1(1)-003
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