ANTI-INFLAMMATORY ACTIVITY AND TOTAL FLAVONOID CONTENT OF AEGLE MARMELOS SEEDS
Journal Title: International Journal of Pharmaceutical Sciences and Drug Research - Year 2011, Vol 3, Issue 3
Abstract
The anti-inflammatory effect of aqueous and methanol extracts of Aegle marmelos seeds was evaluated using carrageenan induced paw edema and cotton pellets induced granuloma in rats. To prove the dependency of pharmacological activity on certain phytoconstituent, total flavonoid contents were estimated, using a spectrophotometric technique. The Quercetin was used as standard compound and the total flavonoids were expressed as mg / g quercetin equivalents (Standard curve equation: y= 0.0009X + 0.0011, R2 = 0.9189). The total flavonoid varied from 3.267 to 12.933 mg/g in extracts. The maximum flavonoid content was found in the methanolic extract (65.20 ± 0.2 mg/g). The methanolic extract administered orally at doses of 200 and 400 mg/kg, b.w. showed highly significant (P<0.01) anti-inflammatory activity. The aqueous extract also produced significant (P<0.05) anti-inflammatory property at the same doses.
Authors and Affiliations
Ganesh N. Sharma, Susheel K. Dubey, Nitin Sati, Jyotsana Sanadya
Keywords
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