ANTI-INFLAMMATORY ACTIVITY OF THE FRACTIONS OF THE AQUEOUS EXTRACT OF Ximenia americana (LINNAEUS)
Journal Title: Int J of Pharm Rev& Res - Year 2015, Vol 5, Issue 2
Abstract
This study is a continuation of previous work during which we studied the effects of aqueous extract of Ximenia americana on inflammation induced by carrageenan on the rat paw. These studies have demonstrated the anti inflammatory action of the aqueous extract of Ximenia americana, its effect seemed to be due to saponins and flavonoids contained in this total extract, so we started to fractionate the total extract of Ximenia americana, to verify the hypothesis that the anti inflammatory effect of aqueous extract of Ximenia americana would be due to saponins and flavonoids. To do this we used the fractionation method developed by Wagner. This method gave us 6 fractions that we tested on rats in which, we injected, into the right hind paw the carrageenan, which causes inflammation in these animals. The study of this inflammation after administration of indomethacin, a reference anti inflammatory, of the aqueous extract of Ximenia americana, and the fractions F2, F4 and F6 showed anti-inflammatory properties of these substances
Authors and Affiliations
Soro TY , Néné-bi AS , Zahoui OS , Yapi HF2
Keywords
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