FORMULATION AND EVALUATION OF FLURBIPROFEN PULSATILE DRUG DELIVERY SYSTEM
Journal Title: Int J of Pharm Rev& Res - Year 2015, Vol 5, Issue 1
Abstract
The aim of present study is to formulate and evaluate Flurbiprofen Pulsatile Drug Delivery system by press coated method to mimic the circadian rhythm of the disease by releasing the drug with a distinct predetermined lag time of 7 hours. The basic design of the system consists of a rapid release core and controlled release coat. A combination of Manucol, Carbopol and Ethyl cellulose was used as a coating material for the tablet. Nine formulations (F1-F9) of the core were prepared by using CCS, SSG and CP as disintegrants in different proportions (2, 4 and 6%) to study the effect of variable concentrations of these on the characteristics of the formulation. Core blend was evaluated for flow properties, hardness, thickness, friability and in-vitro drug release. Among the nine formulations, F3 containing CP (6%) as disintegrant showed a better drug release of 100% over 45 mins was selected .The core was coated with Manucol, Carbopol and EC with different polymer ratios (P1F3- P6F3). Among these, P6F3 was optimized formulation based on the lag time and percent of drug release (98% of drug release in 7 hours). Thus, compression coated tablets with a clear lag time before drug release is a potentially useful formulation for the treatment of RA which follows circadian rhythm
Authors and Affiliations
Srikanth Patel Ch1 , V. Uma Maheshwara Rao1 , CH. S. Vijaya vani1 , B. Raju , P. Sandeep , Shabeena Aqdas1 , P. Raj Kumar2
Keywords
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