Anti-inflammatory agents’ effect on esophageal alkali burn: An experimental study
Journal Title: Dicle Tıp Dergisi - Year 2015, Vol 42, Issue 3
Abstract
Objective: Corrosive burns of the esophagus are some reports demonstrating that the stricture ratio exceeds 50% in the case of a severe burn. In this experimental animal study of rats, we aimed to investigate the effects of the anti-inflammatory agents in esophageal alkali burns. Methods: Twenty-eight Wistar albino rats, weighing from 220 to 250 gr, were used in the study. And following a starving period of 12 hours, we provided general anesthesia with intramuscular ketamin HCL (90 mg/kg) and xylazine (10mg/kg). A corrosive burn just like the corrosive esophagitis was done under general anesthesia. The rats were divided into four groups (7 rats for each). The intraluminal area of 1cm in the esophagus of the rats of the first group was washed using serum physiologic (1 ml). Group II received parenteral antibiotic treatment. Group III received antibiotic and dexamethasone regiment, while the Group IV received antibiotic and prednisolone. Each animal was sacrificed on the 21st day, and their abdominal esophagus was resected for histopathological investigation. The submucosal increase in the collagen, damage to the muscularis mucosa and to the tunica muscularis were three parameters demonstrating the injury histopathologically. Results: There was no injury in the Group I. There was injury in each parameter in the Group II, III, and IV compared with Group I. In the comparison between Group II and III, there was less injury in the Group III. In comparison with Group II there was also significant injury in the muscularis mucosa and the tunica muscularis in the Group I (p<0.05). Conclusion: Prednisolone may decrease the new collagen synthesis that progresses up to muscularis mucosa, but the effect on the lowering the stricture formation is not better than dexamethasone. Key words: Dexamethasone, collagen, corrosive burns of the esophagus, prednisolone
Authors and Affiliations
Semih Koçyiğit, Fatma Koçyiğit, Serpil Bayındır
Keywords
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- EP ID EP153703
- DOI 10.5798/diclemedj.0921.2015.03.0592
- Views 90
- Downloads 0
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