ANTI-TUMOR POTENTIAL OF ERVATAMIA DIVARICATA. L. BURKILL AGAINST EHRLICH ASCITES CARCINOMA
Journal Title: International Journal of Pharmacy and Pharmaceutical Sciences - Year 2015, Vol 7, Issue 7
Abstract
Objective: The present study aims to evaluate the anti-tumor potential of EEED (ethanolic extract of Ervatamia divaricata. L. Burkill) on EAC (Ehrlich ascites carcinoma).Methods: The ethanolic extract of Ervatamia divaricata. L. Burkill was subjected to preliminary phytochemical screening and the antitumor effect of EEED was assessed by employing in-vitro methods. Compounds present in the ethanol extract of the plant were identified using GC-MS (Gas chromatography-mass spectrometry) and attempts were made to understand the mechanism of action using insilico methods.Results: The results of the in vitro cytotoxicity assay and MTT assay revealed the anticancer potential of the ethanol extract of Ervatamia divaricata. When different concentrations of EEED were assayed, the dead cells were found to increase with increase in concentration of the extract. This proved that there was considerable damage of the cell membrane that leads to the blocking of the cell signaling in cancer cells.Conclusion: The present study revealed that EEED possessed significant antitumor activity against EAC.
Authors and Affiliations
Sujitha Parthiban, Ramyapriyadharshini Raman, Meenakshi Sundaram Muthuraman, Brindha Pemaiah
Keywords
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