Anti-Ulcer activity of Simarouba glauca against Ethanol and Indomethacin induced ulcer in rats
Journal Title: International Journal of Research in Pharmacology & Pharmacotherapeutics (IJRPP) - Year 2014, Vol 3, Issue 2
Abstract
Simarouba glauca a member of the Simaroubaceae family, is used in antimicrobial and insecticidal activity, antidysentric, antiherpetic, antihelminthic and antiprotozoal activities, but according to the best of our knowledge there is no scientific detailed report on antioxidant, haemolytic and thrombolytic activities. The purpose of the present study is to investigate the acute oral toxicity and anti-ulcer profile of the Chloroform Extract of Simarouba glauca (CSG) extract in albino rats. No toxicity of extract up to 2000 mg/kg body weight orally as per OECD guidelines No.423. CSG at the doses of 200 and 400 mg/kg body weight orally was administered to evaluate anti- ulcer activity by using Ethanol and indomethacin, induced gastric ulcer models in Albino rats. Chloroform extract of Simarouba glauca dose dependent inhibition in ethanol induced gastric lesions, causing 82.63 % protection at 400 mg/kg, and 53.48 % protection at 200 mg/kg, CSG dose dependent inhibition in indomethacin induced gastric lesions, causing 62.65 % protection at 400 mg/kg and 54.86 % protection at 200 mg/kg, All the results are found to be statistically significant (p≤0.05). Hence we suggest that Chloroform Extract of the leaves of Simarouba glauca was able to decrease the acidity and to increase the mucosal defense in the gastric areas, thereby justifying its use as an antiulcerogenic agent.
Authors and Affiliations
Dr. Shankara sharma
Keywords
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