Anti-ulcer effect of extract of rhizome of Curcuma longa. L against aspirin-induced peptic ulcer in rats
Journal Title: National Journal of Physiology, Pharmacy and Pharmacology - Year 2018, Vol 8, Issue 5
Abstract
Background: Rhizome of Curcuma longa has many therapeutic implications in traditional Indian medicine. It is used in traditional medicine for flatulence, dyspepsia, and other gastric problems. There is conflicting reports regarding its antiulcer and ulcerogenic potential. Aims and Objectives: The study is with the aim of determining the gastoprotective effect of C. longa extract on aspirin-induced gastric ulcer in rats. Materials and Methods: C. longa rhizomes were collected locally. Preparation of extract was done with 50% ethanol using Soxhlet extraction. Albino rats of Wistar strain were used for the study. Aspirin was purchased from Sigma Labs, Mumbai. Anti-ulcer effect of the extract was studied in rats after inducing mucosal damage by aspirin. Results: It was found that extract of C. longa exhibited significant protection against aspirin-induced ulcer at dose levels of 250-mg/kg, 500-mg/kg, and 1000 mg/kg body weight. There is a dose-dependent increase in the ulcer protective action of the extract. Conclusion: The present study with extract of C. longa revealed its anti-ulcer activity.
Authors and Affiliations
Jayan Pariyani Savaringal, Sanalkumar K B
Keywords
Related Articles
- EP ID EP488851
- DOI 10.5455/njppp.2018.8.1249201012018
- Views 38
- Downloads 0
A randomized prospective comparative study of weight gain between asenapine and iloperidone in patients with psychosis
Background: Second-generation antipsychotics (SGAs) are better for psychotic disorders, and they can induce weight gain and other serious metabolic adverse effects which can lead to non-adherence and medical comorbiditie...
Alcoholic extract of Azadirachta indica (Neem) root has no anticonvulsant activity in rodents
Background: Although roots of neem plant have established pharmacological activities such as analgesic, anti-inflammatory, antimicrobial, and anticarcinogenic, there are contradictory results as far as anticonvulsant act...
Comparison of powerpoint with animation enhanced traditional demonstration and traditional practical demonstration in physiology among first year undergraduate medical students
Background: Effective teaching learning activity in physiology practical classes increases learning in cognitive and psychomotor domains with an aim to generate a competent medical graduate. Curre...
Impact of height on sensory nerve conduction
Background: Change in height of the limb not only increases the length of nerve but also causes gradual tapering of nerve with decrease in fiber diameter and myelination. Aim and Objectives: To study the correlation of h...
Biochemical role of serum fructosamine in patients with thyroid disorders
Background: Fructosamine (FA) is the product of a reaction between glucose (sugar) and albumin (protein). It is used to monitor the short - term glycemic changes in patients with diabetes and may have a...