Antiarrhythmic and hypotensive activities of 1-[2-hydroxy-3-(4-phenyl-1-piperazinyl)propyl]-pyrrolidin-2-one (MG-1(R,S)) and its enantiomers.

Journal Title: Pharmacological Reports - Year 2011, Vol 63, Issue 2

Abstract

The compound MG-1(R,S), (1-[2-hydroxy-3(4-phenyl-1-piperazinyl)propyl]-pyrrolidin-2-one, and its enantiomers were tested for electrocardiographic, antiarrhythmic and hypotensive activities. The racemic mixture (MG-1(R,S)) and its S-enantiomer significantly decreased systolic and diastolic blood pressure and possessed antiarrhythmic activity. The S-enantiomer displayed the greatest effect. The R-enantiomer did not show antiarrhythmic or hypotensive activity. The results suggest that the antiarrhythmic and hypotensive effects of these compounds are related to their adrenolytic properties.

Authors and Affiliations

Jacek Sapa, Barbara Filipek, Leszek Nowiński

Keywords

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  • EP ID EP160671
  • DOI -
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How To Cite

Jacek Sapa, Barbara Filipek, Leszek Nowiński (2011). Antiarrhythmic and hypotensive activities of 1-[2-hydroxy-3-(4-phenyl-1-piperazinyl)propyl]-pyrrolidin-2-one (MG-1(R,S)) and its enantiomers.. Pharmacological Reports, 63(2), 455-463. https://europub.co.uk/articles/-A-160671