Antibacterial, Cytotoxic and Analgesic Activities of the Ethanol Extract of Feronia Limonia Linn Fruit Pulp.
Journal Title: IOSR Journal of Pharmacy and Biological Sciences (IOSR-JPBS) - Year 2018, Vol 13, Issue 2
Abstract
The present study was undertaken to explore the antibacterial, cytotoxic and analgesic activities of the ethanolic extract (ET) of Feronia limonia fruit pulp. The pulp of elephant apple was extracted with ethanol by cold extraction procedure. We found that the ET contains active phytochemicals that showed potential antimicrobial, cytotoxic and analgesic activities. Briefly, ET showed better activities on average against both and the highest activity was found against Sarcina lutea (in case of gram positive) and Shigella shiga (in case of gram negative) with significant MIC values. Additionally the ET extract of Feronia limonia fruit pulp possesses cytotoxic activity and LC50 was found to be in the dose of 48.76143μg/ml. Furthermore, analgesic activity of the ET was evaluated using acetic acid-induced writhing model of pain in mice. The crude extract at 200 mg/kg and 400 mg/kg body weight doses displayed significant (p<0.05) reduction in acetic acid induced writhing in mice with the effect of 50.94% and 68.87% respectively which is comparable to the standard diclofenac sodium (81.44%). Prelude phytochemical investigation of the ET showed the presence of alkaloid, saponin, flavonoids and steroids. The results indicated that the ET has moderate antibacterial, cytotoxic and analgesic activities. Keywords:
Authors and Affiliations
Khairul Islam, Md Nurul Islam, Mohammad Mosleh Uddin, Abdullah Al Mamun
Keywords
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- EP ID EP394529
- DOI 10.9790/3008-1302053137
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