ANTIBACTERIAL PROPERTIES OF METHANOL AND AQUEOUS EXTRACTS OF ANOGEISSUS LEIOCARPUS AND TERMINALIA MICROPTERA AGAINST SELECTED ORAL PATHOGENS
Journal Title: World Journal of Pharmaceutical and Medical Research - Year 2017, Vol 3, Issue 8
Abstract
In Africa, chewing sticks are commonly used for maintaining oral hygiene. Phytochemical contents and antibacterial activity of aqueous and methanol extracts of Terminalia microptera and Anogeissus leiocarpus were investigated using standard methods. Qualitative phytochemical screening of the two extracts of T. microptera and A. leiocarpus revealed the presence of all the tested phytochemicals. except anthraquinones, steroids and terpenoids which are absent in aqueous extract of A. leiocarpus. Quantitative phytochemical analysis (mg/100g) indicates the presence of phenols, flavonoids, tannins, saponins and alkaloids at concentration ranging from 805.231±10.83-880.393±6.05, 295.661±100.32-337.556±3.67, 142.321±12.62-253.25±8.56.63, 4.254±0.10-7.338±0.84 and 85.762±10.21-134.231±8.63 respectively. The antibacterial activity of the aqueous and methanol extract of the plants at 20, 30 and 40mg/mL revealed a spectrum of activity which is significant at p<0.05 with the standard drug (Ampiclox and Amoxicilin). Minimum Inhibitory concentration (MIC) and Minimum Bactericidal Concentration (MBC) of the methanol and aqueous extract of the plants ranged from 0.625-10mg/mL and 1.25 – 40mg/mL respectively in all the test organisms. The results revealed the potency of these extracts as a good source of treating orodental and other diseases cause by these pathogens.
Authors and Affiliations
Amuda Oladunni
Keywords
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