ANTIBIOGRAM PROFILING OF HELICOBACTER PYLORI STRAINS AND THE EFFICACY OF BRASSICA CAPITATA AGAINST RESISTANT STRAINS ISOLATED FROM THE PATIENTS SUFFERING FROM GASTRODUODENAL DISEASES IN GUWAHATI, ASSAM
Journal Title: Asian Journal of Pharamceutical and Clinical Research - Year 2018, Vol 11, Issue 8
Abstract
  Objective: Helicobacter pylori resistance toward commonly used antibiotics is increasing leading to the treatment failure; hence, our aim is to determine the antibiogram susceptibility pattern of H. pylori strains isolated from Guwahati, Assam (Northeast India) and also to test the efficacy of the Brassica capitata against the multi and dual drug-resistant strains of North and Northeast India.Methods: Minimum inhibitory concentration of different antibiotics was determined by agar dilution method. Disc diffusion method was used to check the efficacy of B. capitata against clarithromycin (CLR), metronidazole (MTZ), and levofloxacin (LEV)-resistant H. pylori strains.Results: All the H. pylori strains were 100% sensitive to CLR, tetracycline, amoxicillin, and furazolidone. 72.8% of the strains were sensitive toward MTZ and 54.5% were sensitive toward LEV. B. capitata showed good efficacy against the resistant strains of H. pylori of North and Northeast India.Conclusion: Most of the H. pylori strains from Northeast India were sensitive toward the commonly used antibiotics for the treatment regime. B. capitata is effective against H. pylori infection, suggesting its potential as an alternative therapy, and opens the way for further studies on identification of novel antimicrobial targets of B. capitata.
Authors and Affiliations
Shweta Mahant, Valentina Gehlot, Seema Bhatnagar, Megha Rikhi, Asish Kumar Mukhopadhyay, Sangitanjan Dutta, Anil Agarwal, Kunal Das, Rajashree Das
Keywords
Related Articles
- EP ID EP567329
- DOI 10.22159/ajpcr.2018.v11i8.25220
- Views 104
- Downloads 0
the THE EFFECT OF CHITOSAN COATING ON MAFENIDE ACETATE-LOADED LIPOSOME CHARACTERIZATION AND DELIVERY THROUGH BURNED RAT SKIN
Objective: Mafenide acetate has appropriate antibacterial activity against Gram-positive bacteria isolated from the eschar surface. This drug has a high permeability through eschar which causes not only low concentration...
EFFECTS OF DRUGS IN OPTIMIZING BLOOD PRESSURE AND CARDIAC OUTPUT
In the cardiovascular system the drugs effects the conditions like  Peripheral vascular tone ,Inotropic state of the heart ,Chronotropic state of the heart Clinically these drugs are used in ,Acute ischemic heart diseas...
A VALIDATED STABILITY-INDICATING REVERSE-PHASE HIGH-PERFORMANCE LIQUID CHROMATOGRAPHY METHOD FOR DACLATASVIR, IDENTIFICATION AND CHARACTERIZATION OF DEGRADATION PRODUCTS USING LC-ESI-QTOF-MS
Objective: The objective of this study was to report the stability of antiviral drug, daclatasvir (DCV) based on the information obtained from forced degradation studies and characterization of degradation products (DPs)...
PLEIOTROPIC ROLE OF SIMVASTATIN AND ALENDRONATE ON MESENCHYMAL STEM CELLS
Objectives: Previously, our research group has investigated the effect of alendronate (ALN) and simvastatin (SV) in their minimum inhibitory dose (IC50) on oral squamous cell carcinoma cell line where inhibition of angio...
A COMPARATIVE STUDY OF SAFETY AND EFFICACY OF 30% FORMIC ACID WITH 85% FORMIC ACID IN THE TREATMENT OF PALMOPLANTAR WARTS.
 Objective: Warts are a common skin disease seen by dermatologists. It is an infection caused by different strains of human papilloma virus. Thepresence of various topical and systemic treatments for warts is a testamen...