Antibiotic Susceptibility Pattern of Bacteria Causing Lower Respiratory Tract Infections in HIV/AIDS Patients with Correlation to CD4+T Cell Counts
Journal Title: International Journal of Medical Research Professionals - Year 2017, Vol 3, Issue 1
Abstract
Introduction: One of the commonest infectious diseases of humans is lower respiratory tract infection (LRTI). Opportunistic pulmonary disease remains an important cause of acute illness and death in patients with advanced HIV disease. A structured approach to respiratory complaints in these can result in a timely and cost-effective evaluation. Method and Material: Sputum and blood samples were collected from180 HIV sero positives treatment naive patients with lower respiratory tract infection and 100 controls were also taken. Sputum was processed for bacterial pathogens. Antimicrobial susceptibility testing was done using Kirby-Bauer disc diffusion method. CD4 count was estimated using blood sample by Flow cytometry method. Results: All 180 samples yielded growth. Aerobic bacteria isolated were Streptococcus pnemoniae (22.2%) followed by Moraxella catarrhalis (19.4%), Escherichia coli (16.1%), Enterobacter aerogenes (11.7%) and Klebsiella spp, (3.9%). Acid Fast Bacilli were demonstrated in 40.5% samples. Meropenem showed the maximum sensitivity in all Gram negative bacterial isolates in both the groups. Linezolid showed 100% sensitivity to all the Gram positive bacteria in both the groups. CD4 counts in most of them were < 200 cells/cumm. Conclusion: This sensitivity pattern seen in our study can be helpful for clinicians in presenting empirical antimicrobial treatment in this area.
Authors and Affiliations
Jyotsna Chandwani, Nitya Vyas, Saroj Hooja
Keywords
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- EP ID EP542724
- DOI 10.21276/ijmrp.2017.3.1.046
- Views 51
- Downloads 0
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