Comparative Study of Dexmedetomidine and Propofol for Intraoperative Sedation During Surgery Under Regional Anaesthesia
Journal Title: International Journal of Medical Research Professionals - Year 2017, Vol 3, Issue 3
Abstract
Background: Regional anaesthesia offers several benefits to the patients like staying awake, early family contact, early food intake. This study was done to evaluate cardio-respiratory end points at equi-sedative doses of dexmedetomidine and propofol. Secondary end points for comparison were time to achieve sedation onset and offset, postoperative analgesia requirements and psychomotor test performance. Material & Methods: This study was conducted in 80 adult ASA grade I and II patients undergoing surgeries under regional anaesthesia in the department of Anaesthesiology at Santokba Durlabhji Memorial Hospital cum Research Centre, Jaipur (Rajasthan), after approval from the institutional ethical committee. Patients were randomly allocated to dexmedetomidine (Group I) and propofol (Group II) groups. The objective of the study was to compare the efficacy, side effects, and recovery characteristics of dexmedetomidine versus propofol when used for Intra operative sedation. Results: The mean heart rate decreased significantly in both groups in intraoperative period. At the end of surgery it was 69.57±3.48 in group I and 72±5.53 in group II (p value =0.0185, i.e. <0.05). HR changes at different time interval in both group were statistically significant (p<0.05). We did not found any statistically significant difference in respiratory rate at different time intervals compared to baseline value in all groups (p>0.05, i.e., not significant). VAS score changes at different time interval in both groups were statistically significant (p<0.05, i.e. significant). Conclusion: On the basis of results derived in our study, it can be concluded that dexmedetomidine achieve similar levels of sedation to propofol, with a slower onset and offset of sedation. Neither dexmedetomidine nor propofol influence respiratory rate, but propofol result in lower MAP during the intraoperative period.
Authors and Affiliations
Ankita Gupta, V. K. Parashar, Ankur Gupta
Keywords
Related Articles
- EP ID EP548018
- DOI 10.21276/ijmrp.2017.3.3.042
- Views 69
- Downloads 0
Evaluation of Serum Ferritin as an Independent Predictor of Non-alcoholic Steatohepatitis (NASH)
Background: Nonalcoholic fatty liver disease (NAFLD) is one of the most common causes of chronic liver injury. The spectrum of NAFLD ranging from simple fatty liver which in general follows a benign non-progressive clini...
Comparative Study of Intrathecal Fentanyl Versus Intravenous Fentanyl For Supplementation of Subarachnoid Block During Caesarean Section
Background: Pain during cesarean section is a common phenomenon which results release of stress hormone during surgery. In contrast, effective analgesia may permit improved mother-child bonding, early ambulation, dischar...
Symptomatic Medial Humeral Epicondylar Fracture Non-Union: Rare Presentation of a Relatively Common Injury
Background: Symptomatic non-union of medial humeral epicondylar fractures is a limited entity. Some studies recommend surgical excisions of the fragment, but the results are controversial. The purpose of this study is to...
Evaluation of Prevalence and Epidemiological Profile of Type II Diabetes Mellitus: A Cross-Sectional Study at a Tertiary Care Centre
Background: Diabetes mellitus (DM) is a metabolic disorder of chronic hyperglycemia characterized by disturbances to carbohydrate, protein, and fat metabolism resulting from absolute or relative insulin deficiency with d...
Spontaneous Infarction of Fibroadenoma of Breast: Review of Literature And Series of Three Cases
Fibroadenomas are the most common neoplasms of the breast usually affecting adolescents and young women. Infarction in benign breast lesions is rare and It was first described by Delarue and Redon in 1949. This may occur...