Evaluation of Serum Ferritin as an Independent Predictor of Non-alcoholic Steatohepatitis (NASH)
Journal Title: International Journal of Medical Research Professionals - Year 2018, Vol 4, Issue 5
Abstract
Background: Nonalcoholic fatty liver disease (NAFLD) is one of the most common causes of chronic liver injury. The spectrum of NAFLD ranging from simple fatty liver which in general follows a benign non-progressive clinical course to non-alcoholic steatohepatitis (NASH), a more serious form of NAFLD that may progress to cirrhosis and end-stage liver disease. Differentiation between simple steatosis and nonalcoholic steatohepatitis (NASH) is important as NASH may progress to cirrhosis. Till now liver biopsy is gold standard to diagnose NASH. No other specific laboratory or/imaging technique is available to confirm the diagnosis of NASH. Aims: To examine the relationship between serum ferritin and NAFLD severity. Materials & Methods: Demographic, clinical, histologic laboratory and anthropometric data were analyzed in 52 adult patients with biopsy proven NAFLD at a tertiary care center over a 2 year period. We evaluated serum ferritin with respect to histological inflammation and fibrosis in NAFLD patients. The Kleiner scoring system was used to classify NAFLD. Those with concurrent liver diseases and co-existing disease that would alter serum ferritin level were excluded. Patients were stratified into two groups based on their histologic stage of disease: Non NASH fatty liver (NNFL), Non-alcoholic steatohepatitis (NASH). Results: Among 52 patients 25 were diagnosed as NNFL (48.1%) and 27 were diagnosed as NASH (51.9%). No fibrosis was found in 4 (7.7%) patients. Stage 1 fibrosis was found in 41(78.8%) patients, Stage 2 fibrosis was found in 3(5.8%) patients. Stage 3 fibrosis was found in 4 (7.7%) patients and cirrhosis was not found in any patients. On multiple regression analysis, serum ferritin levels had no significant difference in between NNFL and NASH group. Mean serum ferritin level of total 52 patients was 97.29 μg/dl. Among NNFL and NASH patients mean serum ferritin was 94.9 μg/dl and 99.51 μg/dl (P = 0.8). On multiple comparison of serum ferritin value among the different stage of fibrosis, it was also found that stage of fibrosis cannot be predicted by serum ferritin value. Conclusion: Serum ferritin level could not predict the stage of underlying NAFLD disease.
Authors and Affiliations
Md. Zia Hayder Bosunia, Md. Lutful Kabir, Abu Said Md Rahenur Mondol, Syed Abul Foez, Md. Shafiqus Saleheen, Arfin Akter
Keywords
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- EP ID EP536917
- DOI 10.21276/ijmrp.2018.4.5.030
- Views 87
- Downloads 0
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