Antibiotic Susceptibility Pattern of Bacterial Isolates from Surgical Site Infections in a Teaching Hospital, Tirupati, AndhraPradesh
Journal Title: Scholars Academic Journal of Pharmacy - Year 2017, Vol 6, Issue 12
Abstract
Surgical site infection (SSI) is a severe problem in the surgical specialties, which can cause mortality, morbidity, delays incision healing and economic burden. Advances in control of infections have not completely eradicated this problem because of development of drug resistance. Aims and objectives are isolation and identification of the bacterial pathogens from the infection site and determine the antibiotic susceptibility pattern of the isolated pathogens. A total number of 210 clinically suspected cases of surgical site infections in various surgical departments during July 2009 to April 2010 were included. Standard bacteriological methods were used for bacterial isolation and Susceptibiliity testing. Among enrolled cases the age of the patients ranged from ≤20 yrs to ≥ 60 yrs. Out of 210 wound swabs 167/210 were culture positive aerobically yielding 235 bacterial isolates, while 43 were sterile. Of this 112/131 were emergency surgery patients. The maximum rate of isolates was seen after EmLSCS. Of all risk factors pre-operative stay of >7 days was considered as the most significant. All Gram positive cocci isolated were sensitive to Vancomycin (100%), followed by Amikacin and Clindamycin. 81.16% of S.aureus were sensitive to Oxacillin. All Gram negative bacilli isolate showed 100% sensitivity to imipenem. Klebsiellapneumoniae showed 95.35% sensitivity to Amikacin. Escherichia coli showed 91.18% sensitivity to Amikacin, followed by Piperacillin/tazobactam (70.58%). Proteus species showed 100% sensitivity to Amikacin&Piperacillin/tazobactam followed by 80% Ceftrioxone&Ticarcilin/ clavulanate. Pseudomonas aeruginosa showed 100% sensitivity to Imipenem, 82.61% to Amikacin& 80.43% to Piperacillin-tazobactam. Citrobacter species showed 85.71% sensitivity to Amikacin, 71.43% to Piperacillin-tazobactam and 57.14% to Ticarcillin/clavulanate. The present bacteriological study has determined the commonest bacteria and antibiotic susceptibility patterns of the surgical site infections. There is a need to develop national surveillance of antibiotic – resistant organisms. Keywords:Surgical Site Infection, Common Pathogens, Emergency surgeries, Antimicrobial Susceptibility pattern, Antibiotic policy.
Authors and Affiliations
Dr. Chandrakala Penagadam, Shanmugam Yamanaboina, Dr. CH. Srinivasarao
Keywords
Related Articles
- EP ID EP378447
- DOI -
- Views 89
- Downloads 0
Drug-Excipient Interaction Study of Lornoxicam with Polymers
Interaction study is the most important step in reformulation study for the preparation of all dosage forms. The interaction can affect physical, chemical, therapeutic and biological properties and stability of drug and...
Anticonvulsant Activity of Fruit and Leaf Extract of Emblicaofficinalis against Strychnine Induced Convulsions in Albino Mice – A Comparative Study
Epilepsy is the term used for a group of disorders characterized by recurrent spontaneous seizures that apparently result from complex processes involving several neurotransmitter systems such as glutamainergic, choliner...
Isolation and Characterization and Antimicrobial Activity of Calocybe Indica APK-2
Abstract:The present study was aimed to Isolate and characterize the active constituents from higher Basidiomycetes Calocybe Indica Apk-2, an indigenious variety developed by Tamil Nadu Agricultural University, Coimbator...
A facile method of Synthesizing Ayurvedic medicine: Lauha bhasma (iron oxide nanoparticles) & its Characterization
Iron oxide nano particles can be synthesized by various physical and chemical methods which are toxic and harmful for the environment. Ayurveda is a holistic and divine science; a modern method of synthesizing ayurvedic...
Analytical method validation and quantification of raloxifene hydrochloride and its related substance in API using reverse phase - liquid chromatographic method
The present paper describes the reverse phase-high performance liquid chromatographic method and was validated as per ICH guidelines for the determination of related substances in raloxifene hydrochloride. RP-Liquid chro...