Anticonvulsant Activity of Fruit and Leaf Extract of Emblicaofficinalis against Strychnine Induced Convulsions in Albino Mice – A Comparative Study
Journal Title: Scholars Academic Journal of Pharmacy - Year 2017, Vol 6, Issue 12
Abstract
Epilepsy is the term used for a group of disorders characterized by recurrent spontaneous seizures that apparently result from complex processes involving several neurotransmitter systems such as glutamainergic, cholinergic, and gabaergic system. Seizures can arise from virtually any cerebral pathology that increases the excitability of brain tissue. The etiologies can be divided into genetic and acquired brain lesions.Emblicaofficinalisis plant and which is well known fruit and it is called asUsiri or usirikai(Telugu), amalika (Sanskrit), aamla (Hindi), aamla (Gujarati), aavalaa (Marathi), amloki (Bengali), Aula (Punjabi), nellikka (Malayalam), nellikkai (Tamil and Kannada). The present study is aimed to evaluate the anticonvulsant activity of Fruit and leaf extracts of Emblicaofficinalis by Strychnine Induced Convulsions in Mice Model. Here the animals are divided into nine groups Phenytoin sodium 40mg/kg p.ois used as for standard group and test groups received low dose 200mg/kg p.o, medium dose 400mg/kg p.o, high dose 600mg/kg p.o for Fruit and leaf extracts respectively. The results demonstrate the strong anticonvulsant activity of Emblicaofficinalisfruit and leaf extracts (200, 400 & 600 mg/kg) in strychnine induced convulsions. The present study provides the benefits of Emblicaofficinalisfruit and leaf extracts using in the treatment of epilepsy.
Authors and Affiliations
AllaNarayana Rao, Kanagala Priyadarshini, Tanuku Satyanarayana
Keywords
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