ANTIBIOTIC SUSCEPTIBILITY PATTERNS OF AEROBIC BACTERIAL ISOLATES CAUSING WOUND INFECTIONS AMONG THE PATIENTS ATTENDING TO SANTHIRAM GENERAL HOSPITAL, NANDYAL
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2018, Vol 7, Issue 30
Abstract
BACKGROUND The increasing trends in the rate of the antibiotic resistance have now become a serious and an increasingly common concern with severe implications, especially in the surgical departments. These multidrug resistance patterns which include ESBLs, AmpC ßlactamases and metallo-ß-lactamases have emerged as the most worrisome mechanisms of resistance among the gram-negative bacteria, which pose a therapeutic challenge to the healthcare settings. MATERIALS AND METHODS This descriptive study was undertaken to evaluate the profile of aerobic pyogenic bacteria in various pus isolates along with the changing trends in antimicrobial resistance in a tertiary hospital in Nandyal from January 2017 to December 2017. A total of 283 bacterial isolates from 577 clinical samples, which were received over a period of one year were processed. After their identification and their antimicrobial susceptibility testing, they were then screened for the multidrug resistance. RESULTS Among the 283 isolates, most predominant organism was Escherichia coli 63 (22.18%) followed by Pseudomonas aeruginosa 60 (21.13%) and Staphylococcus aureus 58 (20.42%). The antibiogram of gram-positive cocci revealed that they were most susceptible to Vancomycin (100%) and Linezolid (100%). Gram-negative Bacilli are susceptible to Imipenem (96.23%), Cefoperazone + Sulbactam (77.22%) and Netilmicin (75.47%). Of the 212 gram-negative isolates, 143 (67.45%) were ESBL producers followed by 36 (16.98%) AmpC producers and 7 (3.30%) metallo-β-lactamase (MBL) producers. The major ESBL and AmpC producer was Klebsiella pneumoniae, while the MBL production was mainly observed in Pseudomonas aeruginosa. CONCLUSION The high prevalence of the multidrug resistant isolates emphasises the need for a continuous surveillance in the healthcare settings to detect the resistant strains, strict guidelines for the antibiotic therapy and the implementation of infection control measures to reduce the increasing burden of antibiotic resistance.
Authors and Affiliations
Mogalapu Ananda Satya Tej, Sanikommu Sreedevi, Sumanth Kumar G. L. S. , Jinka Balakrishna, Satta Naga Sireesha, Syeda Mariam Seher
Keywords
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- EP ID EP538637
- DOI 10.14260/jemds/2018/758
- Views 48
- Downloads 0
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