EFFECT OF PROPOLIS ON BONE LOSS PREVENTION- A REVIEW
Journal Title: Journal of Evolution of Medical and Dental Sciences - Year 2017, Vol 6, Issue 93
Abstract
BACKGROUND Statement of problem- Bone loss caused by excessive osteoclast formation is the major mechanism underlying many bone diseases leading to problems in dentistry, affecting the treatment plan and patient’s quality of life. Despite many treatment options, a development of novel therapies that are natural, safe, effective and economical is vital for improved strategies against bone loss. Propolis, a natural material that honeybees collect from living plants has been reported to have multiple biological effects including bone loss prevention activities. But there is no systematic review available that has evaluated the effect of propolis on bone loss prevention. MATERIALS AND METHODS The articles with the clinical and in vitro investigations that assessed the prevention and treatment of bone loss using propolis were selected. Electronic database was searched from 1978 to 2016 using the keywords “Propolis” or “propolis” and “bone loss” or “propolis” and “prevention of bone loss.” RESULTS Propolis, which contains a component called Caffeic Acid Phenethyl Ester (CAPE) has an effect on prevention of bone loss. The mechanism of action of CAPE is by inhibiting NF-kappa B and NFAT activation. This in turn results in attenuation of osteoclastogenesis and bone resorption, implying that CAPE can be potential treatment for bone loss prevention. CONCLUSION The literature review suggests that the use of propolis can prevent bone loss. However, as most of the studies were in vitro, there is insufficient reliable evidence to truly provide a recommendation regarding this natural compound. A well-designed, randomised controlled trials are needed to provide answers to these questions.
Authors and Affiliations
Sowmya S, Anil Kumar Gujjari, Mruthunjaya K, Sushma R, Ravi M. B, Raghavendra Swamy K. N
Keywords
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- EP ID EP279580
- DOI 10.14260/jemds/2017/1468
- Views 77
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