Antibody Response after ChAdOx1 nCoV-19 Vaccination in Patients with Type 2 Diabetes at Vajira Hospital
Journal Title: Vajira Medical Journal: Journal of Urban Medicine - Year 2023, Vol 67, Issue 1
Abstract
OBJECTIVE: A question exists as to whether people with diabetes can respond effectively to the COVID-19 vaccine. This study aimed to evaluate antibody response after COVID-19 vaccination in patients with type 2 diabetes. METHODS: This was a cross-sectional analytical study. Two hundred and twelve type 2 diabetes patients were enrolled after receiving a second dose of the ChAdOx1nCoV-19vaccine 3 months previously. Demographic data, medical history, and blood drawn were collected. Antibodies against receptor binding domain (anti-RBD) was investigated in the laboratory department. Other factors that could affect anti-RBD level, i.e. age, gender, BMI, glycemic control, duration of diabetes, and comorbidity, were collected and analyzed. RESULTS: Among 212 patients with type 2 diabetes 3 months after receiving a second dose of the ChAdOx1nCoV-19 vaccine, the anti-RBD level mean was 989.56 U/ml. Patients with type 2 diabetes, with or without cardiovascular disease as a comorbidity, had median anti-RBD levels equal to 258 U/ml and 442 U/ml, respectively. The median of anti-RBD levels between groups had statistically significant differences (p-value = 0.021). Age, gender, BMI, duration of diabetes, glycemic control, and other comorbidities showed no statistically significant differences in the median anti-RBD levels. CONCLUSION: Only patients with type 2 diabetes with cardiovascular disease as a comorbidity showed statistically significant differences in Anti-SARS-CoV-2 response 3 months after receiving a second dose of the ChAdOx1nCoV-19 vaccine. Therefore, patients with diabetes and cardiovascular disease require earlier revaccination to ensure protection against COVID-19 infection.
Authors and Affiliations
Orawan Jedsadatud Swangjit Suraamornkul
Keywords
Related Articles
- EP ID EP723942
- DOI http://dx.doi.org/10.14456/vmj.2023.4
- Views 57
- Downloads 0
Clinical Manifestations of Pulmonary Tuberculosis in Childhood
Objective: To determine clinical presentations related to pulmonary tuberculosis in children. Methods: A retrospective descriptive study was conducted in children less than 15 years old who were diagnosed with pulmonary...
Prevalence of Necrotizing Enterocolitis, Clinical Features and Management of Newborn at Vajira Hospital
Objective: The aim of this study was to evaluate the clinical features, affecting factors and treatment of necrotizing enterocolitis in newborn patients during 5 year period. Methods: A retrospective study of neonates w...
Health-Related Quality of Life among Children with Language Impairment at the Division of Developmental and Behavioral Pediatrics Faculty of Medicine Vajira Hospital: a Cross-Sectional Descriptive Study
Objective: To explore the health-related quality of life (HRQoL) of children with language impairment (LI), and to identify the factors that affect HRQoL in children with LI. Methods: This study was a cross-sectional de...
The Urban Health Themes and Urban Factors Associated with Health: A Brief Review
The current situation is of a population shift from rural to urban areas and is the acceleration of urban growth. In this perspective, comprehending how urbanization has affected human health is critical. Hence, the aim...
Comparison of Surgical Outcomes between a 12-Month Adjustable Intragastric Balloon Placement versus Laparoscopic Sleeve Gastrectomy in Class I-II Obesity: A Retrospective Study
Objective: To compare weight loss between intragastric balloon (IGB) and laparoscopic sleeve gastrectomy (LSG) in patients with class I-II obesity. Materials and Methods: The authors retrospectively reviewed data of obes...