ANTICANCER ACTIVITY OF POLYMERIC NANOPARTICLES CONTAINING ETOPOSIDE USING ALBINO RATS AS EXPERIMENTAL ANIMAL MODEL
Journal Title: Asian Journal of Pharamceutical and Clinical Research - Year 2018, Vol 11, Issue 12
Abstract
Objective: Etoposide is a potent anticancer drug and a major limiting factor that hinders therapeutic use as its high levels of systemic circulation often associated with various off-target effects, particularly cardiotoxicity. The present study focuses on the evaluation of the anticancer activity of optimized etoposide nanoparticles compared with marketed etoposide formulation in experimental animal models.Methods: Albino rats (180–200 g) were used for the study. The anticancer effect of the formulated etoposide nanoparticles was evaluated by induction of hepatocellular carcinoma (HCC). The animals housed in cages and kept on a 12 h light/dark cycle. Following the acclimatization for 1 week, HCC will be induced in rats by adding 100 mg/L of diethylnitrosamine (DENA) in drinking water for 8 weeks. Drug treatment (etoposide [9 mg/kg] in 0.5 % carboxymethyl cellulose; p.o.) can be started at the end of 1 week after cancer induction and dose of 9 mg/kg of etoposide and lyophilized nanoparticles will be administered through oral route on 1, 7, 14, 21, and 28 days. Nanoformulations were evaluated in healthy rats, and anticancer activity was studied in DENA treated rats.Results: The results showed that the polymeric nanoparticles containing etoposide was screened for its anticancer activity by counting the liver nodules of rats with hematoxylin and eosin stain when comparing control and etoposide-treated group.Conclusion: The results of the study concluded that in rats treated with nanoformulations, the numbers of liver nodules were found to be significantly reduced.
Authors and Affiliations
Ayyappan T, Shanmugam S
Keywords
Related Articles
- EP ID EP605202
- DOI 10.22159/ajpcr.2018.v11i12.28127
- Views 91
- Downloads 0
KNOWLEDGE, ATTITUDE, AND BEHAVIORS TOWARD ANTIBIOTICS OF NON-MEDICAL STUDENTS JOUF UNIVERSITY, SAUDI ARABIA
Objective: The objective of the study was to investigate the knowledge and attitude of non-medical students, Jouf University toward antibiotic.Methods: Data were collected from male and female students using a self-prepa...
POTENTIAL SOURCE OF FRESH AND PHOTOACTIVATED GOMUTRA FOR STUDY OF ANTIOXIDANT AND ANTIPATHOGENIC ACTIVITIES AGAINST VARIOUS PATHOGENS
Nowadays, the increase in use of antimicrobial drugs has been attributed to indiscriminate use of broad-spectrum antibiotics, immunosuppressive agents and ongoing epidemics of HIV infection. These drugs are economically...
SUPPLEMENTATION WITH 2:1 RATIO OF N-6:N-3 POLYUNSATURATED FATTY ACID IMPROVES LIVER STEATOSIS AND SERUM CYTOKINE LEVELS IN YOUNG OBESE BALINESE WOMEN: A RANDOMIZED CLINICAL TRIAL
  Objectives: In addition to the rise in obesity prevalence globally, morbidity due to nonalcoholic fatty liver disease is increasing. Primary modalities for preventing and managing this problem include dietary modific...
BIOACTIVE POTENTIAL OF AN EPIBIOTIC STREPTOMYCES STRAIN, CN3 FROM THE SEA FAN JUNCELLA JUNCEA
ABSTRACTObjective: To screen and isolate peptide antibiotics producing epibiotic bacteria from the surface of the sea fan Juncella juncea, and partially purifythe active compound.Methods: In this study, epibiotic bacteri...
ANTIOXIDANT ACTIVITY AND HEPATOPROTECTIVE POTENTIAL OF BALANITES ROXBURGHII FRUITS
ABSTRACTObjectives: The objective of the present study was to evaluate antioxidant activity and hepatoprotective potential of a hydroalcoholic extract ofBalanites roxburghii (BR) fruits.Methods: Extraction was performed...