Anticonvulsant Activities of Ipomea involucrata, Milletia aboensis, and Rauvolfia vomitoria on 4-aminopyridine Induced seizure in Mice
Journal Title: Saudi Journal of Medical and Pharmaceutical Sciences - Year 2017, Vol 3, Issue 11
Abstract
Abstract:The roots of Ipomea involucrate (IP)and Rauvolfia vomitoria (RV) and the leaves of Milletia aboensis (MA) are reportedly used for the treatment of mental illness. This study investigated the anticonvulsant potentials of these plants. Ethanolic crude extracts of IPand RV (50, 100, and 200 mg/kg bw, ip) and MA (100, 200, and 400 mg/kg bw, ip)were administered to respective groups of mice (n=6). The positive control group received 30mg/kg bw, ip of Carbamazepine, while negative control group received 1% DMSO (vehicle). After 30 min, epilepsy was induced by injection of 4-Aminopyrydine (4-AP) (15mg/kg bw ip). They were observed for the next 30min. The ability of the extracts to delay the onset of trembling, hindlimb extension, seizure, and protect from death as compared to the untreated group was taken as a sign of anticonvulsant activity. Ethanolic crude extracts of MA,RVandIPpossess anticonvulsant potencies in the order -MA>RV>IP; with MA protecting two-thirds of animals against death from 4-AP-induced seizures. The plant extracts have the potentials of tackling generalized tonic-clonic and partial seizures. MA and RV may exert their effects by acting on ion channels while IP is most likely to act via other mechanisms. Keywords:Anticonvulsant; Ipomea involucrate; Milletia aboensis;Rauvolfia vomitoria; 4-aminopyridine; Mice
Authors and Affiliations
David-Oku E, Ekpenyong EU, Edet EE, Akuodor GC, Obiajunwa-Otteh JI, Inwang EU
Keywords
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