Hepatorenoprotective Potential of Cocos nucifera (coconut)Juice in Normal Male Humans
Journal Title: Saudi Journal of Medical and Pharmaceutical Sciences - Year 2018, Vol 4, Issue 12
Abstract
This study evaluated the tendency for Cocos nucifera juice to be effective in management of hepatic and renal anomalies in a human design. 180 male subjects were used for this study. With treatment A as the control, Cocos nucifera juice was administered in 3 doses; B, C, D-50ml, 100ml and 150ml respectively. The experimental period lasted for 42 days. The biochemical assay protocols were aimed at investigating changes relating to hepatorenal function. Biomarkers assayed for include aspartate transaminase, alanine transaminase and alkaline phosphatase for liver function biomarkers, creatinine, cystacin-3 and interleukin-18 for kidney function biomarkers. There was a dose dependent change in both liver and kidney function biomarkers. This study revealed an inverse relationship between Cocos nucifera juice ingestion and the serum level of these metabolic biomarkers. There was also a time dependent reduction as well as a progressive decrease in harmonic mean of the assayed biomarkers for all dose treatments. Cocos nucifera has the potential to be applied in the management of hepatic and renal dysfunction.
Authors and Affiliations
Ilochi Ogadinma, Kolawole Tolunigba Abisola, Arthur Nwafor Chuemere, Bassey Samuel, Paul Moundipa
Keywords
Related Articles
- EP ID EP488097
- DOI -
- Views 91
- Downloads 0
Preliminary Characterization of Novel Gum Obtained from Myrianthus arboreus Leaves as Pharmaceutical Excipient
Abstract:Polymeric materials obtained from plant sources have become very versatile excipients for the formulation of pharmaceutical dosage form especially tablet dosage form. This study was aimed at the preliminary char...
Barriers to Reporting Medication Administration Errors among Nurses in Services Hospital Lahore
Abstract:According to the report of Institute of Medicine (IOM) that about 7,000 of death are occur annual because of the medication error which is going worse day by day. The effect of medication error is not good for p...
Immobilization of Pepper Chitosanase on Different Natural Carriers for Improving Enzyme Stability
Abstract:The aimed of this work, was improved the stability of the chitosanase enzyme by immobilization with different natural carriers to enhance the economic of industrial biocatalytic process. It was used in preparati...
Efficacy of Intermittent and Continuous Subglottic Secretion Drainage in Ventilator-Associated Pneumonia Reduction among Critically Ill Ventilated Patients: An Integrative Review
Abstract: Ventilator-associated pneumonia (VAP) is the most common nosocomial infection in critical care settings and affects between 9%-27% of mechanically ventilated patients for more than 48 or 72 hours. One of the st...
Cryptococcus neoformans: An Opportunistic Pathogen with an Unusual Presentation in a Renal Transplant Recipient
Abstract: Cryptococcal infection is characteristically associated with immunocompromised status. In most cases, the skin lesions represent a sentinel finding for disseminated cryptococcal infection. We describe a case of...