ANTICONVULSANT ACTIVITY OF MORINGA OLEIFERA LEAF
Journal Title: International Research Journal of Pharmacy (IRJP) - Year 2011, Vol 2, Issue 7
Abstract
Moringa oleifera which is commonly known as drumstick tree has been used for its nutrition value and extensively used as a CNS depressant traditionally. Present work has been carried out to evaluate the anticonvulsant activity of methanolic extract of M. oleifera leaves against pentylenetetrazole (PTZ) and maximal electroshock (MES) induced convulsions at different dose level (200 mg/kg and 400 mg/kg i.p.). Diazepam and phenytoin (5mg/kg i.p. and 25mg/kg i.p., respectively) were used as a reference standard. At both the doses it significantly (P < 0.0001) delayed the onset of clonic seizures in PTZ induced convulsions and significantly reduced (P < 0.0001) duration of hind limb extension in MES test. The phytochemical investigation of plant revealed the presence of alkaloids, flavonoids, tannins and saponins as major constituents. The data obtained indicates that methanolic extract of M. oleifera leaves may help to control grand mal and petit mal epilepsy.
Authors and Affiliations
Amrutia Jay, Minaxi Lala , U. Srinivasa , A. R. Shabaraya , Rajan Moses
Keywords
Related Articles
- EP ID EP155864
- DOI -
- Views 94
- Downloads 0
CRITICAL APPRAISAL OF AGNIKARMA AND ITS THERAPEUTIC ASPECTS
Sushruta known as father of surgery has described various surgical procedures along with some para-surgical measures. ‘Agni karma’ is one amongst these parasurgical procedures. In Agnikarma therapeutic burning with speci...
ISOLATION AND FREEZE DRYING OF CERTAIN PROBIOTIC STRAINS
The aim of the present study was to evaluate few probiotics strains available commercially in Lahore city and isolation and identification of strains from these commercial probiotics. The identified and isolated probioti...
SYNTHESIS AND BIOLOGICAL EVALUATION OF (E)-3-(2-(4-SUBSTITUTEDPHENYL)-1H-INDOLE-3-YL)-(4-SUBSTITUTEDPHENYL) PROP-2-EN-1-ONE AS ANTI-INFLAMMATORY AGENTS
The reaction of 2-aryl-1H-indole-3-carboxaldehydes with substituted acetophenones in ethylene glycol and piperidine as a base gives the (E)-3-(2-(4-substitutedphenyl)-1H-indol-3-yl)-(4-substitutedphenyl) prop-2-en-1-one...
EVALUATION OF NIMBA TAILA AND MANJISTHA CHURNA IN NON HEALING ULCER
This clinical study was done in fifty-one cases of non-healing ulcers of more than six weeks duration to evaluate the efficacy of Nimba taila (Neem oil) externally and Manjistha churna (powder) orally as well as its kwat...
DESIGNING OF COLON SPECIFIC MATRIX TABLET OF DIETHYL CARBAMAZINE CITRATE FOR THE TREATMENT OF FILARIASIS
The main aim of the study was to develop colon specific sustained release matrix tablets of diethyl carbamazine citrate (DEC), an anthelmintic for improving patient compliance, delivered to colon for its effective action...