Antidepressant-like effect of combined treatment with selective sigma receptor agonists and a 5-HT(1A) receptor agonist in the forced swimming test in rats.

Journal Title: Pharmacological Reports - Year 2007, Vol 59, Issue 6

Abstract

The interaction between the selective sigma (sigma) receptor agonists and 8-OH-DPAT, a serotonin (5-HT)(1A) receptor agonist, was examined in the forced swimming test in rats. The results indicate that joint administration of DTG (5 mg/kg) or SA4503 (3 mg/kg), the selective sigma(1)/sigma(2)- or sigma(1)-receptor agonists, respectively, and 8-OH-DPAT (0.1 or 0.3 mg/kg) induces an antidepressant-like effect. The doses of sigma agonists and 8-OH-DPAT used in the study were inactive per se in this model. The effect of DTG and 8-OH-DPAT co-administration was partly counteracted by WAY100635 (0.1 mg/kg) as well as by BD 1047 (3 mg/kg), a 5-HT(1A) and sigma(1) receptor antagonists, respectively, suggesting the involvement of both receptor types in the anti-immobility effect in rats.

Authors and Affiliations

Grażyna Skuza, Zofia Rogóż

Keywords

Related Articles

In vivo effects of high-dose methotrexate on bone remodeling in rats.

Methotrexatae (MTX) is a folate antagonist. MTX osteopathy is well recognized to accompany a high-dose therapy with this drug for the treatment of childhood malignancy. Clinical tests also show that low-dose MTXused in t...

NSAID loxoprofen inhibits high threshold or wide dynamic range neuronal responses in the rat at different time-courses.

The onset of the antinociceptive effect with loxoprofen sodium (LOX), a non-steroidal anti-inflammatory drug, was examined electrophysiologically during carrageenan-induced hindpaw inflammation in the rat. Extracellular...

Influence of bupropion and calcium channel antagonists on the nicotine-induced memory-related response of mice in the elevated plus maze.

In this study, we investigated the effects of acute administration of nicotine on memory-related behavior in mice using the elevated plus maze test. In this test, the time necessary for mice to move from the open arm to...

Kynurenic acid and kynurenine aminotransferases in retinal aging and neurodegeneration.

The kynurenine aminotransferases (KATs) KAT I and KAT II are pivotal to the synthesis of kynurenic acid (KYNA), the only known endogenous glutamate receptor antagonist and neuroprotectant. KAT I and II have been found in...

Are anti-inflammatory properties of lipoic acid associated with the formation of hydrogen sulfide?

Lipoic acid (LA) was shown to possess anti-inflammatory properties. In this study, we present evidence supporting the hypothesis that the anti-inflammatory properties of LA are associated with the formation of hydrogen s...

Download PDF file
  • EP ID EP134018
  • DOI -
  • Views 92
  • Downloads 0

How To Cite

Grażyna Skuza, Zofia Rogóż (2007). Antidepressant-like effect of combined treatment with selective sigma receptor agonists and a 5-HT(1A) receptor agonist in the forced swimming test in rats.. Pharmacological Reports, 59(6), 773-777. https://europub.co.uk/articles/-A-134018