Abstract

Objective: To prescreen the in vivo anti diabetic activity of the aerial parts of the plant Aerva lanata Family Amaranthaceae by using alloxan inducing diabetic rats. Method: In the present study to investigate the effect of alcoholic extract of Aerva lanata was selected for phytochemical and anti diabetic activity. Anti diabetic activity was determined by reduction of increased blood glucose level alloxan-induced diabetic rat. Result: Preliminary phytochemical screening of alcoholic extract of Aerva lanata(AEAL) showed the presence of alkaloids,flavonoids,terpinoids,carbohydrates,sterols,tannins,saponins,cardioglycosides,ami no acids, proteins, methyl grevillate, lupeol, lupeol acetate benzoic acid and β-sitosteryl acetate. The antidiabetic activity of AEAL determined by using the alloxan induced diabetic rats shows that the effect of decreased the blood glucose level. The reduction of blood glucose level in 2nd week by (P<0.01) significantly. Conclusion: Aerva lanata have been used in medicine due to various biological activities. This study indicates that the alcoholic extract of Aerva lanata possesses potential anti diabetic activity. The presence of alkaloids in alcoholic extraction of the aerial parts of the plants Aervalanata appears to contribute to its activity. Further investigation requires to confirm this activity.

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