ANTIDIABETIC ACTIVITY OF CALOTROPIS GIGANTEA WHITE FLOWER EXTRACTS IN ALLOXAN INDUCED DIABETIC RATS
Journal Title: Journal of Drug Delivery and Therapeutics - Year 2017, Vol 7, Issue 3
Abstract
Calotropis gigantea white (Asclepiadaceae) has been documented as a traditional treatment of diabetes. The aim of this study was to evaluate the antidiabetic activity of chloroform and ethyl acetate extracts from the flower in normal and alloxan-induced diabetic rats. Blood samples were obtained and blood glucose levels were analyzed employing a glucometer at different time intervals on 1st, 4th, 8th and 12th day of the treatment with C. gigantea white extracts compare to glibenclamide (10 mg / kg). From the results, it is revealed that the test chloroform, and ethyl acetate extracts at a dose level 500 mg / kg, showed a significant reduction in blood sugar level day in a progressive manner comparable to glibenclamide. Biochemical parameters, including hemoglobin, urea, creatinine, serum cholesterol, low-density lipoprotein (LDL), and high-density lipoprotein (HDL) were also assessed. Treatment of diabetic rats with the two extracts of this plant restored the elevated biochemical parameters significantly (p<0.05) to the normal level. It also proves the traditional claim with regard to C. gigantea white for its anti-diabetic activity.
Authors and Affiliations
R Manivannan
Keywords
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- EP ID EP295551
- DOI 10.22270/jddt.v7i3.1447
- Views 96
- Downloads 0
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